Purkey HE - Search Results

1

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.

Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW. Purkey HE, et al. Chem Biol. 2004 Dec;11(12):1719-28. doi: 10.1016/j.chembiol.2004.10.009. Chem Biol. 2004. PMID: 15610856

2

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors.

Razavi H, Powers ET, Purkey HE, Adamski-Werner SL, Chiang KP, Dendle MT, Kelly JW. Razavi H, et al. Among authors: purkey he. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1075-8. doi: 10.1016/j.bmcl.2004.12.022. Bioorg Med Chem Lett. 2005. PMID: 15686915

3

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Johnson SM, et al. Among authors: purkey he. J Med Chem. 2005 Mar 10;48(5):1576-87. doi: 10.1021/jm049274d. J Med Chem. 2005. PMID: 15743199

4

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.

Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Razavi H, et al. Among authors: purkey he. Angew Chem Int Ed Engl. 2003 Jun 23;42(24):2758-61. doi: 10.1002/anie.200351179. Angew Chem Int Ed Engl. 2003. PMID: 12820260 No abstract available.

5

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.

Petrassi HM, Johnson SM, Purkey HE, Chiang KP, Walkup T, Jiang X, Powers ET, Kelly JW. Petrassi HM, et al. Among authors: purkey he. J Am Chem Soc. 2005 May 11;127(18):6662-71. doi: 10.1021/ja044351f. J Am Chem Soc. 2005. PMID: 15869287

6

Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors.

Oza VB, Petrassi HM, Purkey HE, Kelly JW. Oza VB, et al. Among authors: purkey he. Bioorg Med Chem Lett. 1999 Jan 4;9(1):1-6. doi: 10.1016/s0960-894x(98)00696-9. Bioorg Med Chem Lett. 1999. PMID: 9990446

7

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma.

Purkey HE, Dorrell MI, Kelly JW. Purkey HE, et al. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5566-71. doi: 10.1073/pnas.091431798. Proc Natl Acad Sci U S A. 2001. PMID: 11344299 Free PMC article.

8

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Peterson SA, et al. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12956-60. doi: 10.1073/pnas.95.22.12956. Proc Natl Acad Sci U S A. 1998. PMID: 9789022 Free PMC article.

9

Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry.

McCammon MG, Scott DJ, Keetch CA, Greene LH, Purkey HE, Petrassi HM, Kelly JW, Robinson CV. McCammon MG, et al. Among authors: purkey he. Structure. 2002 Jun;10(6):851-63. doi: 10.1016/s0969-2126(02)00771-2. Structure. 2002. PMID: 12057199 Free article.

10

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

Boudreau A, Purkey HE, Hitz A, Robarge K, Peterson D, Labadie S, Kwong M, Hong R, Gao M, Del Nagro C, Pusapati R, Ma S, Salphati L, Pang J, Zhou A, Lai T, Li Y, Chen Z, Wei B, Yen I, Sideris S, McCleland M, Firestein R, Corson L, Vanderbilt A, Williams S, Daemen A, Belvin M, Eigenbrot C, Jackson PK, Malek S, Hatzivassiliou G, Sampath D, Evangelista M, O'Brien T. Boudreau A, et al. Among authors: purkey he. Nat Chem Biol. 2016 Oct;12(10):779-86. doi: 10.1038/nchembio.2143. Epub 2016 Aug 1. Nat Chem Biol. 2016. PMID: 27479743

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