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Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.
Burkhart CA, Watt F, Murray J, Pajic M, Prokvolit A, Xue C, Flemming C, Smith J, Purmal A, Isachenko N, Komarov PG, Gurova KV, Sartorelli AC, Marshall GM, Norris MD, Gudkov AV, Haber M. Burkhart CA, et al. Cancer Res. 2009 Aug 15;69(16):6573-80. doi: 10.1158/0008-5472.CAN-09-1075. Epub 2009 Aug 4. Cancer Res. 2009. PMID: 19654298 Free PMC article.
Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.
Koman IE, Commane M, Paszkiewicz G, Hoonjan B, Pal S, Safina A, Toshkov I, Purmal AA, Wang D, Liu S, Morrison C, Gudkov AV, Gurova KV. Koman IE, et al. Among authors: purmal aa. Cancer Prev Res (Phila). 2012 Aug;5(8):1025-35. doi: 10.1158/1940-6207.CAPR-11-0529. Epub 2012 Jun 11. Cancer Prev Res (Phila). 2012. PMID: 22689915
Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models.
Dermawan JK, Hitomi M, Silver DJ, Wu Q, Sandlesh P, Sloan AE, Purmal AA, Gurova KV, Rich JN, Lathia JD, Stark GR, Venere M. Dermawan JK, et al. Among authors: purmal aa. Cancer Res. 2016 Apr 15;76(8):2432-42. doi: 10.1158/0008-5472.CAN-15-2162. Epub 2016 Feb 26. Cancer Res. 2016. PMID: 26921329 Free PMC article.
Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling.
Kirsanov K, Fetisov T, Lesovaya EA, Maksimova V, Trukhanova L, Antoshina E, Gor'kova T, Morozova O, Safina A, Fleyshman D, Salimov R, Shipaeva E, Ivanov R, Leonov A, Purmal AA, Belitsky GA, Gudkov AV, Gurova KV, Yakubovskaya MG. Kirsanov K, et al. Among authors: purmal aa. Cancer Prev Res (Phila). 2020 Jan;13(1):53-64. doi: 10.1158/1940-6207.CAPR-19-0198. Epub 2019 Oct 25. Cancer Prev Res (Phila). 2020. PMID: 31653646
Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.
Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV, Gurova KV. Gasparian AV, et al. Among authors: purmal aa. Sci Transl Med. 2011 Aug 10;3(95):95ra74. doi: 10.1126/scitranslmed.3002530. Sci Transl Med. 2011. PMID: 21832239 Free PMC article.
Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.
Carter DR, Murray J, Cheung BB, Gamble L, Koach J, Tsang J, Sutton S, Kalla H, Syed S, Gifford AJ, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, Ling D, Kim PY, Webber H, Clark A, Ruhle M, Liu B, Oberthuer A, Fischer M, Byrne J, Saletta F, Thwe le M, Purmal A, Haderski G, Burkhart C, Speleman F, De Preter K, Beckers A, Ziegler DS, Liu T, Gurova KV, Gudkov AV, Norris MD, Haber M, Marshall GM. Carter DR, et al. Sci Transl Med. 2015 Nov 4;7(312):312ra176. doi: 10.1126/scitranslmed.aab1803. Sci Transl Med. 2015. PMID: 26537256 Free PMC article.
48 results