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The irrationality of the present use of the osmole gap: applicable physical chemistry principles and recommendations to improve the validity of current practices.
Koga Y, Purssell RA, Lynd LD. Koga Y, et al. Among authors: purssell ra. Toxicol Rev. 2004;23(3):203-11. doi: 10.2165/00139709-200423030-00006. Toxicol Rev. 2004. PMID: 15862086 Review.
Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap.
Purssell RA, Pudek M, Brubacher J, Abu-Laban RB. Purssell RA, et al. Ann Emerg Med. 2001 Dec;38(6):653-9. doi: 10.1067/mem.2001.119455. Ann Emerg Med. 2001. PMID: 11719745
The use of the osmole gap as a screening test for the presence of exogenous substances.
Purssell RA, Lynd LD, Koga Y. Purssell RA, et al. Toxicol Rev. 2004;23(3):189-202. doi: 10.2165/00139709-200423030-00005. Toxicol Rev. 2004. PMID: 15862085 Review.
An evaluation of the osmole gap as a screening test for toxic alcohol poisoning.
Lynd LD, Richardson KJ, Purssell RA, Abu-Laban RB, Brubacher JR, Lepik KJ, Sivilotti ML. Lynd LD, et al. Among authors: purssell ra. BMC Emerg Med. 2008 Apr 28;8:5. doi: 10.1186/1471-227X-8-5. BMC Emerg Med. 2008. PMID: 18442409 Free PMC article.
Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole.
Lepik KJ, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD, Kennedy JR, Daws DE, Brignall JL. Lepik KJ, et al. Among authors: purssell ra. Ann Emerg Med. 2009 Apr;53(4):439-450.e10. doi: 10.1016/j.annemergmed.2008.05.008. Epub 2008 Jul 18. Ann Emerg Med. 2009. PMID: 18639955
Medication errors associated with the use of ethanol and fomepizole as antidotes for methanol and ethylene glycol poisoning.
Lepik KJ, Sobolev BG, Levy AR, Purssell RA, Dewitt CR, Erhardt GD, Baker JL, Kennedy JR, Daws DE. Lepik KJ, et al. Among authors: purssell ra. Clin Toxicol (Phila). 2011 Jun;49(5):391-401. doi: 10.3109/15563650.2011.580754. Clin Toxicol (Phila). 2011. PMID: 21740138
Naloxone interventions in opioid overdoses: a systematic review protocol.
Shaw LV, Moe J, Purssell R, Buxton JA, Godwin J, Doyle-Waters MM, Brasher PMA, Hau JP, Curran J, Hohl CM. Shaw LV, et al. Syst Rev. 2019 Jun 11;8(1):138. doi: 10.1186/s13643-019-1048-y. Syst Rev. 2019. PMID: 31186071 Free PMC article.
Renal failure caused by mushroom poisoning.
Leathem AM, Purssell RA, Chan VR, Kroeger PD. Leathem AM, et al. Among authors: purssell ra. J Toxicol Clin Toxicol. 1997;35(1):67-75. doi: 10.3109/15563659709001168. J Toxicol Clin Toxicol. 1997. PMID: 9022655
Fibrinolytic administration for acute myocardial infarction in a tertiary ED: factors associated with an increased door-to-needle time.
Zed PJ, Abu-Laban RB, Cadieu TM, Purssell RA, Filiatrault L. Zed PJ, et al. Among authors: purssell ra. Am J Emerg Med. 2004 May;22(3):192-6. doi: 10.1016/j.ajem.2004.02.005. Am J Emerg Med. 2004. PMID: 15138955
Aluminum toxicity following IV use of oral methadone solution.
Friesen MS, Purssell RA, Gair RD. Friesen MS, et al. Among authors: purssell ra. Clin Toxicol (Phila). 2006;44(3):307-14. doi: 10.1080/15563650600637077. Clin Toxicol (Phila). 2006. PMID: 16749550
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