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Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Purushotham A, et al. Cell Metab. 2009 Apr;9(4):327-38. doi: 10.1016/j.cmet.2009.02.006. Cell Metab. 2009. PMID: 19356714 Free PMC article.
SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. ...When challenged with a high-fat diet, liver-specific SIRT1 knockout mice develop hepatic steatosis, hepatic inflammation, and endopl …
SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. .. …
Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis.
Kazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li X. Kazgan N, et al. Gastroenterology. 2014 Apr;146(4):1006-16. doi: 10.1053/j.gastro.2013.12.029. Epub 2013 Dec 31. Gastroenterology. 2014. PMID: 24389307 Free PMC article.
Intestine-specific deletion of SIRT1 increased hepatic bile acid biosynthesis, reduced hepatic accumulation of bile acids, and protected animals from liver damage from a diet high in levels of bile acids. CONCLUSIONS: Intestinal SIRT1, a key nutrient sensor, is requ …
Intestine-specific deletion of SIRT1 increased hepatic bile acid biosynthesis, reduced hepatic accumulation of bile acids, and protected ani …
Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.
Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X. Purushotham A, et al. Mol Cell Biol. 2012 Apr;32(7):1226-36. doi: 10.1128/MCB.05988-11. Epub 2012 Jan 30. Mol Cell Biol. 2012. PMID: 22290433 Free PMC article.
SIRT1, a highly conserved NAD(+)-dependent protein deacetylase, is a key metabolic sensor that directly links nutrient signals to animal metabolic homeostasis. ...Here we report that deletion of hepatic SIRT1 reduces the expression of farnesoid X receptor (FXR), …
SIRT1, a highly conserved NAD(+)-dependent protein deacetylase, is a key metabolic sensor that directly links nutrient signals …
Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding.
Purushotham A, Xu Q, Li X. Purushotham A, et al. FASEB J. 2012 Feb;26(2):656-67. doi: 10.1096/fj.11-195172. Epub 2011 Oct 17. FASEB J. 2012. PMID: 22006157 Free PMC article.
Here, we investigated the systemic functions of SIRT1 in metabolic homeostasis by utilizing a whole-body SIRT1 heterozygous mouse model. ...Taken together, our findings indicate that SIRT1 plays a vital role in the regulation of systemic energy and steroid hormone h …
Here, we investigated the systemic functions of SIRT1 in metabolic homeostasis by utilizing a whole-body SIRT1 heterozygous mouse mod …
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.
Schug TT, Xu Q, Gao H, Peres-da-Silva A, Draper DW, Fessler MB, Purushotham A, Li X. Schug TT, et al. Mol Cell Biol. 2010 Oct;30(19):4712-21. doi: 10.1128/MCB.00657-10. Epub 2010 Jul 20. Mol Cell Biol. 2010. PMID: 20647536 Free PMC article.
Macrophage activation and infiltration into resident tissues is known to mediate local inflammation and is a hallmark feature of metabolic syndrome. ...In this study, we demonstrate that SIRT1 modulates the acetylation status of the RelA/p65 subunit of NF-κB and thus plays …
Macrophage activation and infiltration into resident tissues is known to mediate local inflammation and is a hallmark feature of meta …
SIRT1 performs a balancing act on the tight-rope toward longevity.
Purushotham A, Schug TT, Li X. Purushotham A, et al. Aging (Albany NY). 2009 Jul 30;1(7):669-73. doi: 10.18632/aging.100076. Aging (Albany NY). 2009. PMID: 20157548 Free PMC article.
Our recent study defined a new role for SIRT1 as a regulator of hepatic lipid metabolism. In the liver a major target of this sirtuin is the PPARalpha/PGC-1alpha signaling axis. ...
Our recent study defined a new role for SIRT1 as a regulator of hepatic lipid metabolism. In the liver a major target o …
Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats.
Purushotham A, Shrode GE, Wendel AA, Liu LF, Belury MA. Purushotham A, et al. J Nutr Biochem. 2007 Oct;18(10):676-84. doi: 10.1016/j.jnutbio.2006.10.008. Epub 2007 Mar 21. J Nutr Biochem. 2007. PMID: 17368879
Here, we hypothesized that CLA decreases hepatic steatosis in a diet-induced model of obesity in rats which are resistant to the adipose-lowering effects of CLA. To investigate this, we fed male Wistar rats a high-fat (20%) diet for 4 weeks to induce obesity and hep …
Here, we hypothesized that CLA decreases hepatic steatosis in a diet-induced model of obesity in rats which are resistant to the adip …
Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice.
Wendel AA, Purushotham A, Liu LF, Belury MA. Wendel AA, et al. J Lipid Res. 2008 Jan;49(1):98-106. doi: 10.1194/jlr.M700195-JLR200. Epub 2007 Sep 28. J Lipid Res. 2008. PMID: 17906221
In a 2 x 2 factorial design, 6 week old male ob/ob mice were fed either a control diet or a diet supplemented with CLA and received daily intraperitoneal injections of either leptin or vehicle for 4 weeks. ...
In a 2 x 2 factorial design, 6 week old male ob/ob mice were fed either a control diet or a diet supplemented with CLA …
Conjugated linoleic acid induces uncoupling protein 1 in white adipose tissue of ob/ob mice.
Wendel AA, Purushotham A, Liu LF, Belury MA. Wendel AA, et al. Lipids. 2009 Nov;44(11):975-82. doi: 10.1007/s11745-009-3348-9. Epub 2009 Sep 25. Lipids. 2009. PMID: 19779754
Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for 4 weeks. A third group of mice (LEPTIN) was fed the control diet and received daily injections of recombinant leptin as a pos …
Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for …
The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells.
Purushotham A, Tian M, Belury MA. Purushotham A, et al. Mol Nutr Food Res. 2009 Feb;53(2):300-7. doi: 10.1002/mnfr.200700514. Mol Nutr Food Res. 2009. PMID: 19035551
Further, naringenin did not increase phosphorylation of Akt at Ser473 or, Thr308, indicating this down-stream target of PI3-kinase is also not a player in naringenin-mediated suppression of hepatic glucose production. ...Together, these results suggest that the aglycone, n …
Further, naringenin did not increase phosphorylation of Akt at Ser473 or, Thr308, indicating this down-stream target of PI3-kinase is also n …
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