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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
Nat Commun. 2015 Mar 31;6:6715. doi: 10.1038/ncomms7715.
Nat Commun. 2015.
PMID: 25823686
Free PMC article.
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
Hameed P S, Patil V, Solapure S, Sharma U, Madhavapeddi P, Raichurkar A, Chinnapattu M, Manjrekar P, Shanbhag G, Puttur J, Shinde V, Menasinakai S, Rudrapatana S, Achar V, Awasthy D, Nandishaiah R, Humnabadkar V, Ghosh A, Narayan C, Ramya VK, Kaur P, Sharma S, Werngren J, Hoffner S, Panduga V, Kumar CN, Reddy J, Kumar K N M, Ganguly S, Bharath S, Bheemarao U, Mukherjee K, Arora U, Gaonkar S, Coulson M, Waterson D, Sambandamurthy VK, de Sousa SM.
Hameed P S, et al. Among authors: puttur j.
J Med Chem. 2014 Jun 12;57(11):4889-905. doi: 10.1021/jm500432n. Epub 2014 May 23.
J Med Chem. 2014.
PMID: 24809953
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Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
P SH, Solapure S, Mukherjee K, Nandi V, Waterson D, Shandil R, Balganesh M, Sambandamurthy VK, Raichurkar AK, Deshpande A, Ghosh A, Awasthy D, Shanbhag G, Sheikh G, McMiken H, Puttur J, Reddy J, Werngren J, Read J, Kumar M, R M, Chinnapattu M, Madhavapeddi P, Manjrekar P, Basu R, Gaonkar S, Sharma S, Hoffner S, Humnabadkar V, Subbulakshmi V, Panduga V.
P SH, et al. Among authors: puttur j.
Antimicrob Agents Chemother. 2014;58(1):61-70. doi: 10.1128/AAC.01751-13. Epub 2013 Oct 14.
Antimicrob Agents Chemother. 2014.
PMID: 24126580
Free PMC article.
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Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding.
Hameed P S, Manjrekar P, Raichurkar A, Shinde V, Puttur J, Shanbhag G, Chinnapattu M, Patil V, Rudrapatana S, Sharma S, Kumar CN, Nandishaiah R, Madhavapeddi P, Sriram D, Solapure S, Sambandamurthy VK.
Hameed P S, et al. Among authors: puttur j.
ACS Med Chem Lett. 2015 May 22;6(7):741-6. doi: 10.1021/ml500531p. eCollection 2015 Jul 9.
ACS Med Chem Lett. 2015.
PMID: 26191359
Free PMC article.
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4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors.
Borkar MR, Nandan S, Nagaraj HKM, Puttur J, Manniyodath J, Chatterji D, Coutinho EC.
Borkar MR, et al. Among authors: puttur j.
Med Chem. 2019;15(1):28-37. doi: 10.2174/1573406414666180525075755.
Med Chem. 2019.
PMID: 29793410
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Design, synthesis and SAR of antitubercular benzylpiperazine ureas.
Satish S, Chitral R, Kori A, Sharma B, Puttur J, Khan AA, Desle D, Raikuvar K, Korkegian A, Martis EAF, Iyer KR, Coutinho EC, Parish T, Nandan S.
Satish S, et al. Among authors: puttur j.
Mol Divers. 2022 Feb;26(1):73-96. doi: 10.1007/s11030-020-10158-3. Epub 2021 Jan 1.
Mol Divers. 2022.
PMID: 33385288
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