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A DEAD protein that activates intron self-splicing without unwinding RNA.
Solem A, Zingler N, Pyle AM. Solem A, et al. Mol Cell. 2006 Nov 17;24(4):611-7. doi: 10.1016/j.molcel.2006.10.032. Mol Cell. 2006. PMID: 17188036
RNA folding.
Pyle AM, Green JB. Pyle AM, et al. Curr Opin Struct Biol. 1995 Jun;5(3):303-10. doi: 10.1016/0959-440x(95)80091-3. Curr Opin Struct Biol. 1995. PMID: 7583628 Review.
Ribozymes: a distinct class of metalloenzymes.
Pyle AM. Pyle AM. Science. 1993 Aug 6;261(5122):709-14. doi: 10.1126/science.7688142. Science. 1993. PMID: 7688142 Review.
Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships.
Michels WJ Jr, Pyle AM. Michels WJ Jr, et al. Biochemistry. 1995 Mar 7;34(9):2965-77. doi: 10.1021/bi00009a028. Biochemistry. 1995. PMID: 7893710
Catalytic role of 2'-hydroxyl groups within a group II intron active site.
Abramovitz DL, Friedman RA, Pyle AM. Abramovitz DL, et al. Science. 1996 Mar 8;271(5254):1410-3. doi: 10.1126/science.271.5254.1410. Science. 1996. PMID: 8596912
Branch-site selection in a group II intron mediated by active recognition of the adenine amino group and steric exclusion of non-adenine functionalities.
Liu Q, Green JB, Khodadadi A, Haeberli P, Beigelman L, Pyle AM. Liu Q, et al. J Mol Biol. 1997 Mar 21;267(1):163-71. doi: 10.1006/jmbi.1996.0845. J Mol Biol. 1997. PMID: 9096215
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