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Calculation of pKas in RNA: on the structural origins and functional roles of protonated nucleotides.
Tang CL, Alexov E, Pyle AM, Honig B. Tang CL, et al. Among authors: pyle am. J Mol Biol. 2007 Mar 9;366(5):1475-96. doi: 10.1016/j.jmb.2006.12.001. Epub 2006 Dec 6. J Mol Biol. 2007. PMID: 17223134
RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.
Pyle AM, Murphy FL, Cech TR. Pyle AM, et al. Nature. 1992 Jul 9;358(6382):123-8. doi: 10.1038/358123a0. Nature. 1992. PMID: 1377367
RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Cech TR, Herschlag D, Piccirilli JA, Pyle AM. Cech TR, et al. Among authors: pyle am. J Biol Chem. 1992 Sep 5;267(25):17479-82. J Biol Chem. 1992. PMID: 1381347 Review. No abstract available.
Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups.
Pyle AM, Cech TR. Pyle AM, et al. Nature. 1991 Apr 18;350(6319):628-31. doi: 10.1038/350628a0. Nature. 1991. PMID: 1708111
Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.
Pyle AM, McSwiggen JA, Cech TR. Pyle AM, et al. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8187-91. doi: 10.1073/pnas.87.21.8187. Proc Natl Acad Sci U S A. 1990. PMID: 2236030 Free PMC article.
RNA folding.
Pyle AM, Green JB. Pyle AM, et al. Curr Opin Struct Biol. 1995 Jun;5(3):303-10. doi: 10.1016/0959-440x(95)80091-3. Curr Opin Struct Biol. 1995. PMID: 7583628 Review.
Ribozymes: a distinct class of metalloenzymes.
Pyle AM. Pyle AM. Science. 1993 Aug 6;261(5122):709-14. doi: 10.1126/science.7688142. Science. 1993. PMID: 7688142 Review.
Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships.
Michels WJ Jr, Pyle AM. Michels WJ Jr, et al. Among authors: pyle am. Biochemistry. 1995 Mar 7;34(9):2965-77. doi: 10.1021/bi00009a028. Biochemistry. 1995. PMID: 7893710
Building a kinetic framework for group II intron ribozyme activity: quantitation of interdomain binding and reaction rate.
Pyle AM, Green JB. Pyle AM, et al. Biochemistry. 1994 Mar 8;33(9):2716-25. doi: 10.1021/bi00175a047. Biochemistry. 1994. PMID: 8117737
Catalytic role of 2'-hydroxyl groups within a group II intron active site.
Abramovitz DL, Friedman RA, Pyle AM. Abramovitz DL, et al. Among authors: pyle am. Science. 1996 Mar 8;271(5254):1410-3. doi: 10.1126/science.271.5254.1410. Science. 1996. PMID: 8596912
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