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Sphingosine 1-phosphate signalling in mammalian cells.
Pyne S, Pyne NJ. Pyne S, et al. Among authors: pyne nj. Biochem J. 2000 Jul 15;349(Pt 2):385-402. doi: 10.1042/0264-6021:3490385. Biochem J. 2000. PMID: 10880336 Free PMC article. Review.
Phosphorylation of the recombinant spliced variants of the alpha-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase A.
Pyne NJ, Freissmuth M, Pyne S. Pyne NJ, et al. Among authors: pyne s. Biochem Biophys Res Commun. 1992 Jul 31;186(2):1081-6. doi: 10.1016/0006-291x(92)90857-h. Biochem Biophys Res Commun. 1992. PMID: 1497643
However, the phosphorylation was inhibited by guanine nucleotides (GDP-beta-S, GppNHp and GTP) and is, therefore, a specific event. We suggest that, as for GS alpha phosphorylation by protein kinase C (Pyne et al., 1992), the guanine nucleotide-free form of GS alpha …
However, the phosphorylation was inhibited by guanine nucleotides (GDP-beta-S, GppNHp and GTP) and is, therefore, a specific event. W …
Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C.
Pyne S, Pyne NJ. Pyne S, et al. Among authors: pyne nj. Biochem J. 1995 Oct 15;311 ( Pt 2)(Pt 2):637-42. doi: 10.1042/bj3110637. Biochem J. 1995. PMID: 7487907 Free PMC article.
Phosphatidic acid phosphohydrolase in guinea-pig airway smooth muscle.
Tolan DG, Pyne NJ, Pyne S. Tolan DG, et al. Among authors: pyne nj, pyne s. Biochem Soc Trans. 1995 May;23(2):198S. doi: 10.1042/bst023198s. Biochem Soc Trans. 1995. PMID: 7672218 No abstract available.
Phospholipase D regulation involves extracellular calcium as a conditional requirement for subsequent stimulation by protein kinase C.
Pyne S, Pyne NJ. Pyne S, et al. Among authors: pyne nj. Biochem Soc Trans. 1995 May;23(2):199S. doi: 10.1042/bst023199s. Biochem Soc Trans. 1995. PMID: 7672219 No abstract available.
PKC-dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin-stimulated ERK-2 pathway.
Pyne NJ, Stevens P, Moughal N, Pyne S. Pyne NJ, et al. Among authors: pyne s. Biochem Soc Trans. 1995 May;23(2):200S. doi: 10.1042/bst023200s. Biochem Soc Trans. 1995. PMID: 7672220 No abstract available.
Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.
Moughal N, Stevens PA, Kong D, Pyne S, Pyne NJ. Moughal N, et al. Among authors: pyne s, pyne nj. Biochem J. 1995 Mar 15;306 ( Pt 3)(Pt 3):723-6. doi: 10.1042/bj3060723. Biochem J. 1995. PMID: 7702566 Free PMC article.
We concluded that the cyclic AMP signal limits the magnitude of ERK-2 activation [Pyne, Moughal, Stevens, Tolan and Pyne (1994) Biochem. ...
We concluded that the cyclic AMP signal limits the magnitude of ERK-2 activation [Pyne, Moughal, Stevens, Tolan and Pyne (1994 …
Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation.
Pyne NJ, Moughal N, Stevens PA, Tolan D, Pyne S. Pyne NJ, et al. Among authors: pyne s. Biochem J. 1994 Dec 1;304 ( Pt 2)(Pt 2):611-6. doi: 10.1042/bj3040611. Biochem J. 1994. PMID: 7998998 Free PMC article.
Bradykinin activates adenylate cyclase via a pathway that involves the 'up-stream' regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) …
Bradykinin activates adenylate cyclase via a pathway that involves the 'up-stream' regulation of phospholipase D (PLD)-catalysed hydrolysis …
Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways.
Stevens PA, Pyne S, Grady M, Pyne NJ. Stevens PA, et al. Among authors: pyne s, pyne nj. Biochem J. 1994 Jan 1;297 ( Pt 1)(Pt 1):233-9. doi: 10.1042/bj2970233. Biochem J. 1994. PMID: 8280104 Free PMC article.
Bradykinin stimulates phospholipase D in primary cultures of guinea-pig tracheal smooth muscle.
Pyne S, Pyne NJ. Pyne S, et al. Among authors: pyne nj. Biochem Pharmacol. 1993 Feb 9;45(3):593-603. doi: 10.1016/0006-2952(93)90132-g. Biochem Pharmacol. 1993. PMID: 8442759
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