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Page 1
Did you mean pyradiomycin (1 results)?
Characterization of Pyridomycin B Reveals the Formation of Functional Groups in Antimycobacterial Pyridomycin.
Huang T, Zhou Z, Wei M, Chen L, Xiao Z, Deng Z, Lin S. Huang T, et al. Appl Environ Microbiol. 2022 Mar 22;88(6):e0203521. doi: 10.1128/AEM.02035-21. Epub 2022 Feb 2. Appl Environ Microbiol. 2022. PMID: 35108072 Free PMC article.
Site-directed mutation identified that His154 in the active site is a critical residue for pyridomycin B production. These findings will improve our understanding of pyridomycin biosynthetic logic, identify the missing link for the double bound formation of enol est …
Site-directed mutation identified that His154 in the active site is a critical residue for pyridomycin B production. These findings w …
The chemistry of pyridomycin.
Ogawara H, Maeda K, Koyama G, Naganawa H, Umezawa H. Ogawara H, et al. Chem Pharm Bull (Tokyo). 1968 Apr;16(4):679-87. doi: 10.1248/cpb.16.679. Chem Pharm Bull (Tokyo). 1968. PMID: 5677624 Free article. No abstract available.
Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis.
Zhou Z, Yang X, Huang T, Zheng J, Deng Z, Dai S, Lin S. Zhou Z, et al. ACS Chem Biol. 2023 Jan 20;18(1):141-150. doi: 10.1021/acschembio.2c00773. Epub 2022 Dec 14. ACS Chem Biol. 2023. PMID: 36517246
Pyridomycin is a potent antimycobacterial natural product by specifically inhibiting InhA, a clinically validated antituberculosis drug discovery target. Pyridyl moieties of pyridomycin play an essential role in inhibiting InhA by occupying the reduced form of the n …
Pyridomycin is a potent antimycobacterial natural product by specifically inhibiting InhA, a clinically validated antituberculosis dr …
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Hartkoorn RC, Pojer F, Read JA, Gingell H, Neres J, Horlacher OP, Altmann KH, Cole ST. Hartkoorn RC, et al. Nat Chem Biol. 2014 Feb;10(2):96-8. doi: 10.1038/nchembio.1405. Epub 2013 Dec 1. Nat Chem Biol. 2014. PMID: 24292073
Pyridomycin, a natural product with potent antituberculosis activity, inhibits a major drug target, the InhA enoyl reductase. ...Proof-of-principle studies show how structure-assisted drug design can improve the activity of new pyridomycin derivatives....
Pyridomycin, a natural product with potent antituberculosis activity, inhibits a major drug target, the InhA enoyl reductase. ...Proo …
The biosynthesis of pyridomycin. I.
Ogawara H, Maeda K, Umezawa H. Ogawara H, et al. Biochemistry. 1968 Sep;7(9):3296-302. doi: 10.1021/bi00849a037. Biochemistry. 1968. PMID: 5684351 No abstract available.
Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin.
Kienle M, Eisenring P, Stoessel B, Horlacher OP, Hasler S, van Colen G, Hartkoorn RC, Vocat A, Cole ST, Altmann KH. Kienle M, et al. J Med Chem. 2020 Feb 13;63(3):1105-1131. doi: 10.1021/acs.jmedchem.9b01457. Epub 2020 Jan 21. J Med Chem. 2020. PMID: 31904960
A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2 side chain attached to the macrocyclic core structure by a C-C single bond, in place of the synthetically more demanding enol ester double bond found in the natural …
A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2 side chain attached to th …
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.
Hartkoorn RC, Sala C, Neres J, Pojer F, Magnet S, Mukherjee R, Uplekar S, Boy-Röttger S, Altmann KH, Cole ST. Hartkoorn RC, et al. EMBO Mol Med. 2012 Oct;4(10):1032-42. doi: 10.1002/emmm.201201689. Epub 2012 Sep 17. EMBO Mol Med. 2012. PMID: 22987724 Free PMC article.
By selecting pyridomycin-resistant mutants of Mycobacterium tuberculosis, whole-genome sequencing and genetic validation, we identified the NADH-dependent enoyl- (Acyl-Carrier-Protein) reductase InhA as the principal target and demonstrate that pyridomycin inhibits …
By selecting pyridomycin-resistant mutants of Mycobacterium tuberculosis, whole-genome sequencing and genetic validation, we identifi …
A new antibiotic, pyridomycin.
MAEDA K, KOSAKA H, OKAMI Y, UMEZAWA H. MAEDA K, et al. J Antibiot (Tokyo). 1953 Jul;6(3):140. J Antibiot (Tokyo). 1953. PMID: 13096450 No abstract available.
Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517.
Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z. Huang T, et al. J Biol Chem. 2011 Jun 10;286(23):20648-57. doi: 10.1074/jbc.M110.180000. Epub 2011 Mar 22. J Biol Chem. 2011. PMID: 21454714 Free PMC article.
Pyridomycin is a structurally unique antimycobacterial cyclodepsipeptide containing rare 3-(3-pyridyl)-l-alanine and 2-hydroxy-3-methylpent-2-enoic acid moieties. The biosynthetic gene cluster for pyridomycin has been cloned and identified from Streptomyces pyridomy …
Pyridomycin is a structurally unique antimycobacterial cyclodepsipeptide containing rare 3-(3-pyridyl)-l-alanine and 2-hydroxy-3-meth …
A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling.
Caradec T, Anoz-Carbonell E, Petrov R, Billamboz M, Antraygues K, Cantrelle FX, Boll E, Beury D, Hot D, Drobecq H, Trivelli X, Hartkoorn RC. Caradec T, et al. ACS Cent Sci. 2023 Nov 10;9(11):2138-2149. doi: 10.1021/acscentsci.3c00965. eCollection 2023 Nov 22. ACS Cent Sci. 2023. PMID: 38033789 Free PMC article.
Genome analysis of a soil bacterium, Dactylosporangium fulvum, found a "hybrid" biosynthetic gene cluster responsible for the production of both an antibiotic, pyridomycin, and a novel chlorocatechol-containing siderophore named chlorodactyloferrin. ...We then found that t …
Genome analysis of a soil bacterium, Dactylosporangium fulvum, found a "hybrid" biosynthetic gene cluster responsible for the production of …
25 results