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49 results

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Page 1
Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways(TM)) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial.
Pokushalov E, Ponomarenko A, Bayramova S, Garcia C, Pak I, Shrainer E, Ermolaeva M, Kudlay D, Johnson M, Miller R. Pokushalov E, et al. Nutrients. 2024 May 21;16(11):1550. doi: 10.3390/nu16111550. Nutrients. 2024. PMID: 38892484 Free PMC article. Clinical Trial.
Exploring the link between genetic polymorphisms in folate metabolism genes (MTHFR, MTR, and MTRR) and cardiovascular disease (CVD), this study evaluates the effect of B vitamin supplements (methylfolate, pyridoxal-5'-phosphate, and methylcobalamin) on homocy …
Exploring the link between genetic polymorphisms in folate metabolism genes (MTHFR, MTR, and MTRR) and cardiovascular disease (CVD), this st …
Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study.
Bayat A, Aledo-Serrano A, Gil-Nagel A, Korff CM, Thomas A, Boßelmann C, Weber Y, Gardella E, Lund AM, de Sain-van der Velden MGM, Møller RS. Bayat A, et al. Dev Med Child Neurol. 2022 Jun;64(6):789-798. doi: 10.1111/dmcn.15142. Epub 2022 Jan 26. Dev Med Child Neurol. 2022. PMID: 35080266 Free article.
AIM: To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy. ...The EEG was repeated after reaching maxim …
AIM: To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) i …
Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia.
Adelufosi AO, Abayomi O, Ojo TM. Adelufosi AO, et al. Cochrane Database Syst Rev. 2015 Apr 13;2015(4):CD010501. doi: 10.1002/14651858.CD010501.pub2. Cochrane Database Syst Rev. 2015. PMID: 25866243 Free PMC article.
While there are no known effective treatments for tardive dyskinesia to date, some reports suggest that pyridoxal 5 phosphate may be effective in reducing the severity of tardive dyskinesia symptoms. OBJECTIVES: To determine the effectiveness of pyridoxal …
While there are no known effective treatments for tardive dyskinesia to date, some reports suggest that pyridoxal 5 phospha …
Reported Awareness and Use of Pyridoxal-5'-Phosphate Supplementation in Alanine Aminotransferase and Aspartate Aminotransferase Assay Reagents: A Survey by the College of American Pathologists Clinical Chemistry Committee.
Chambliss AB, Souers RJ, Genzen JR, Manthei DM. Chambliss AB, et al. Arch Pathol Lab Med. 2025 May 1;149(5):400-404. doi: 10.5858/arpa.2024-0097-CP. Arch Pathol Lab Med. 2025. PMID: 39048110 Free article.
.-: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) assay reagents are available both with and without supplementation with pyridoxal-5'-phosphate (P5P; the active form of vitamin B6), a catalytic cofactor required for their enzymat …
.-: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) assay reagents are available both with and without supplementation w …
Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency.
Guerriero RM, Patel AA, Walsh B, Baumer FM, Shah AS, Peters JM, Rodan LH, Agrawal PB, Pearl PL, Takeoka M. Guerriero RM, et al. Pediatr Neurol. 2017 Nov;76:47-53. doi: 10.1016/j.pediatrneurol.2017.05.024. Epub 2017 Jun 3. Pediatr Neurol. 2017. PMID: 28985901 Free PMC article.
OBJECTIVE: Pyridoxine is converted to its biologically active form pyridoxal-5-phosphate (P5P) by the enzyme pyridox(am)ine 5'-phosphate oxidase and serves as a cofactor in nearly 200 reactions in the central nervous system. Pyridox(am)ine 5'- …
OBJECTIVE: Pyridoxine is converted to its biologically active form pyridoxal-5-phosphate (P5P) by the enzyme pyr …
Supplementation of pyridoxal-5'-phosphate in aminotransferase reagents: a matter of patient safety.
Panteghini M. Panteghini M. Clin Chem Lab Med. 2025 Aug 12;63(12):2377-2380. doi: 10.1515/cclm-2025-0947. Print 2025 Nov 25. Clin Chem Lab Med. 2025. PMID: 40788350
The obtaining of the harmonization in aminotransferase results is however strongly dependent on supplementation of pyridoxal-5'-phosphate (P-5-P) in aminotransferase reagents as this exclusively enables reporting of measured values on clinical samples that ar …
The obtaining of the harmonization in aminotransferase results is however strongly dependent on supplementation of pyridoxal-5 …
The effect of pyridoxal-5-phosphate on serum alanine aminotransferase activity in dogs suffering from canine babesiosis.
Myburgh EC, Goddard A. Myburgh EC, et al. Onderstepoort J Vet Res. 2009 Sep;76(3):327-33. doi: 10.4102/ojvr.v76i3.38. Onderstepoort J Vet Res. 2009. PMID: 21105601
Accurate measurements of serum aminotransferase (ALT) activity in dogs relies on the endogenous pro-enzyme pyridoxal 5-phosphate (P5P). The purpose of this study was to determine whether the exclusion of P5P from the analytical method causes an …
Accurate measurements of serum aminotransferase (ALT) activity in dogs relies on the endogenous pro-enzyme pyridoxal 5-phos …
A high performance liquid chromatography fluorescence method for the analysis of both pyridoxal-5-phosphate and thiamine pyrophosphate in whole blood.
Nguyen VL, Darman M, Ireland A, Fitzpatrick M. Nguyen VL, et al. Clin Chim Acta. 2020 Jul;506:129-134. doi: 10.1016/j.cca.2020.03.026. Epub 2020 Mar 18. Clin Chim Acta. 2020. PMID: 32197927
BACKGROUND AND AIMS: The active coenzymes of the water soluble vitamins B1 and B6 (thiamine pyrophosphate (TPP) and pyridoxal-5-phosphate (P5P) respectively) play an important role in numerous bodily functions. ...In this study we developed a novel met …
BACKGROUND AND AIMS: The active coenzymes of the water soluble vitamins B1 and B6 (thiamine pyrophosphate (TPP) and pyridoxal-5 …
A randomized, double-blind, crossover study on the pharmacokinetics of a novel formulation of CoQ10 with pyridoxal 5'-phosphate and phosphatidyl choline.
Evans M, Sharma P, Guthrie N. Evans M, et al. J Diet Suppl. 2010 Dec;7(4):314-24. doi: 10.3109/19390211.2010.522551. Epub 2010 Oct 11. J Diet Suppl. 2010. PMID: 22432561 Clinical Trial.
The pharmacokinetics of a single 30-mg dose of a novel enteric-coated coenzyme Q10 (CoQ(10)) formulation with pyridoxal 5'-phosphate and phosphatidyl choline (CoQ(10)-P5P-PC) was investigated against two comparators CoQ(10) (NPN 02176955) and CoQ(10) ( …
The pharmacokinetics of a single 30-mg dose of a novel enteric-coated coenzyme Q10 (CoQ(10)) formulation with pyridoxal 5'- …
Instant Hydrogelation Inspired by Inflammasomes.
Wang H, Feng Z, Lu A, Jiang Y, Wu H, Xu B. Wang H, et al. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7579-7583. doi: 10.1002/anie.201702783. Epub 2017 May 24. Angew Chem Int Ed Engl. 2017. PMID: 28481474 Free PMC article.
Based on the recent near-atomic structures of the PYRIN domain of ASC in the protein filament of inflammasomes and the observation that the active form of vitamin B6 (pyridoxal phosphate, P5P) modulates the self-assembly of ASC, we rationally designed an N-te …
Based on the recent near-atomic structures of the PYRIN domain of ASC in the protein filament of inflammasomes and the observation that the …
49 results