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Page 1
Showing results for bryostatin
Search for Pyrostatin instead (3 results)
Bryostatin-1: a novel PKC inhibitor in clinical development.
Kortmansky J, Schwartz GK. Kortmansky J, et al. Cancer Invest. 2003;21(6):924-36. doi: 10.1081/cnv-120025095. Cancer Invest. 2003. PMID: 14735696 Review.
Short-term exposure to bryostatin-1 promotes activation of PKC, whereas prolonged exposure promotes significant downregulation of PKC. In numerous hematological and solid tumor cell lines, bryostatin-1 inhibits proliferation, induces differentiation, a …
Short-term exposure to bryostatin-1 promotes activation of PKC, whereas prolonged exposure promotes significant downregulation …
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.
Sun MK, Alkon DL. Sun MK, et al. CNS Drug Rev. 2006 Spring;12(1):1-8. doi: 10.1111/j.1527-3458.2006.00001.x. CNS Drug Rev. 2006. PMID: 16834754 Free PMC article. Review.
Bryostatin-1 is a powerful protein kinase C (PKC) agonist, activating PKC isozymes at nanomolar concentrations. Pharmacological studies of bryostatin-1 have mainly been focused on its action in preventing tumor growth. Emerging evidence suggests, howev …
Bryostatin-1 is a powerful protein kinase C (PKC) agonist, activating PKC isozymes at nanomolar concentrations. Pharmacologica …
Bryostatin-1 Decreases HIV-1 Infection and Viral Production in Human Primary Macrophages.
Hany L, Turmel MO, Barat C, Ouellet M, Tremblay MJ. Hany L, et al. J Virol. 2022 Feb 23;96(4):e0195321. doi: 10.1128/JVI.01953-21. Epub 2021 Dec 8. J Virol. 2022. PMID: 34878918 Free PMC article.
Bryostatin-1 treatment of infected MDMs led to decreased amounts of capsid and matrix mature proteins with little to no modulation of precursors. Our observations revealed that bryostatin-1-treated myeloid and CD4(+) T cells respond differently upon HI …
Bryostatin-1 treatment of infected MDMs led to decreased amounts of capsid and matrix mature proteins with little to no modula …
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination.
Gharibani P, Abramson E, Shanmukha S, Smith MD, Godfrey WH, Lee JJ, Hu J, Baydyuk M, Dorion MF, Deng X, Guo Y, Calle AJ, A Hwang S, Huang JK, Calabresi PA, Kornberg MD, Kim PM. Gharibani P, et al. Sci Transl Med. 2025 Jan 8;17(780):eadk3434. doi: 10.1126/scitranslmed.adk3434. Epub 2025 Jan 8. Sci Transl Med. 2025. PMID: 39772770
Here, we found that the protein kinase C (PKC)-modulating drug bryostatin-1 (bryo-1), a CNS-penetrant compound with an established human safety profile, shifts the transcriptional programs of microglia and CNS-associated macrophages from a proinflammatory phenotype …
Here, we found that the protein kinase C (PKC)-modulating drug bryostatin-1 (bryo-1), a CNS-penetrant compound with an establi …
Munc13 Is a Molecular Target of Bryostatin 1.
Blanco FA, Czikora A, Kedei N, You Y, Mitchell GA, Pany S, Ghosh A, Blumberg PM, Das J. Blanco FA, et al. Biochemistry. 2019 Jul 9;58(27):3016-3030. doi: 10.1021/acs.biochem.9b00427. Epub 2019 Jun 20. Biochemistry. 2019. PMID: 31243993 Free PMC article.
Bryostatin 1 is a natural macrolide shown to improve neuronal connections and enhance memory in mice. ...Lastly, we observed an increased level of expression of Munc13-1 following a 24 h incubation with bryostatin 1 in both HT22 and primary mouse hippo …
Bryostatin 1 is a natural macrolide shown to improve neuronal connections and enhance memory in mice. ...Lastly, we observed a …
The chemistry and biology of the bryostatin antitumour macrolides.
Hale KJ, Hummersone MG, Manaviazar S, Frigerio M. Hale KJ, et al. Nat Prod Rep. 2002 Aug;19(4):413-53. doi: 10.1039/b009211h. Nat Prod Rep. 2002. PMID: 12195811 Review.
This review summarises the main developments that have occurred in bryostatin chemistry over the period 1982 to 2001 and has 117 references....
This review summarises the main developments that have occurred in bryostatin chemistry over the period 1982 to 2001 and has 117 refe …
Bryostatin-1 inhibits cell proliferation of hepatocarcinoma and induces cell cycle arrest by activation of GSK3beta.
Wang J, Wang Z, Sun Y, Liu D. Wang J, et al. Biochem Biophys Res Commun. 2019 May 7;512(3):473-478. doi: 10.1016/j.bbrc.2019.03.014. Epub 2019 Mar 20. Biochem Biophys Res Commun. 2019. PMID: 30904158
We also found a significant inhibitory action of bryostatin-1 (100, 200 nM) on CyclinD1 activity in PLC/PRF/5 cells, and bryostatin-1 can promote ubiquitination-dependent protein degradation of CyclinD1 in PLC/PRF/5 cells. Western blot results confirme …
We also found a significant inhibitory action of bryostatin-1 (100, 200 nM) on CyclinD1 activity in PLC/PRF/5 cells, and br …
Bryostatin-1 alleviates experimental multiple sclerosis.
Kornberg MD, Smith MD, Shirazi HA, Calabresi PA, Snyder SH, Kim PM. Kornberg MD, et al. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2186-2191. doi: 10.1073/pnas.1719902115. Epub 2018 Feb 12. Proc Natl Acad Sci U S A. 2018. PMID: 29440425 Free PMC article.
In contrast, compartmentalized inflammation within the CNS, including diffuse activation of innate myeloid cells, characterizes the progressive phase of MS, the most debilitating phase that currently lacks satisfactory treatments. Recently, bryostatin-1 (bryo-1), a …
In contrast, compartmentalized inflammation within the CNS, including diffuse activation of innate myeloid cells, characterizes the progress …
Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11.
Li L, Zhao M, van Meurs M, Brouwers-Haspels I, den Dekker RJH, Wilmsen MEP, Grashof DGB, van de Werken HJG, Rao S, Rokx C, Mueller YM, Katsikis PD. Li L, et al. Front Immunol. 2025 Jan 14;15:1509874. doi: 10.3389/fimmu.2024.1509874. eCollection 2024. Front Immunol. 2025. PMID: 39877358 Free PMC article.
Therefore, we further investigated how bryostatin-1 directly impacts exhausted CD8+ T cells. METHODS: PBMCs from people with HIV (PWH) were treated with bryostatin-1 and tracked with proliferation dye for cell expansion. ...RNA-seq revealed that mitoge …
Therefore, we further investigated how bryostatin-1 directly impacts exhausted CD8+ T cells. METHODS: PBMCs from people with H …
1,003 results