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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1926 1
1946 6
1947 10
1948 16
1949 6
1950 19
1951 32
1952 55
1953 60
1954 87
1955 81
1956 75
1957 66
1958 64
1959 89
1960 59
1961 75
1962 121
1963 175
1964 226
1965 250
1966 249
1967 286
1968 383
1969 500
1970 482
1971 545
1972 613
1973 667
1974 718
1975 670
1976 664
1977 660
1978 670
1979 702
1980 768
1981 884
1982 784
1983 814
1984 974
1985 1083
1986 1057
1987 1068
1988 1139
1989 1230
1990 1431
1991 1323
1992 1342
1993 1445
1994 1460
1995 1395
1996 1379
1997 1547
1998 1551
1999 1746
2000 1767
2001 1751
2002 1640
2003 1776
2004 1864
2005 2019
2006 2197
2007 2298
2008 2285
2009 2261
2010 2515
2011 2616
2012 2687
2013 2676
2014 2586
2015 2644
2016 2588
2017 2522
2018 2540
2019 2466
2020 2495
2021 2249
2022 1931
2023 1520
2024 586

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81,913 results

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Page 1
Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance.
Wang Y, Xiao J, Meng A, Liu C. Wang Y, et al. Molecules. 2022 Aug 24;27(17):5420. doi: 10.3390/molecules27175420. Molecules. 2022. PMID: 36080188 Free PMC article. Review.
Herein, we comprehensively summarized the different synthetic approaches to the preparation of multivalent pyrrolidine clusters, from total synthesis of divalent iminosugars to complex architectures bearing twelve pyrrolidine motifs. ...We envision that this compreh …
Herein, we comprehensively summarized the different synthetic approaches to the preparation of multivalent pyrrolidine clusters, from …
Cascade reactions in nanoreactors.
van Oers MC, Rutjes FP, van Hest JC. van Oers MC, et al. Curr Opin Biotechnol. 2014 Aug;28:10-6. doi: 10.1016/j.copbio.2013.10.011. Epub 2013 Nov 17. Curr Opin Biotechnol. 2014. PMID: 24832069 Review.
Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds.
Li Petri G, Raimondi MV, Spanò V, Holl R, Barraja P, Montalbano A. Li Petri G, et al. Top Curr Chem (Cham). 2021 Aug 10;379(5):34. doi: 10.1007/s41061-021-00347-5. Top Curr Chem (Cham). 2021. PMID: 34373963 Free PMC article. Review.
The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human diseases. ...In this review, we report bioactive molecules with target selectivity characterized by the pyrrolidine …
The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the …
Structure-Activity Relationship Analysis of Cocrystallized Gliptin-like Pyrrolidine, Trifluorophenyl, and Pyrimidine-2,4-Dione Dipeptidyl Peptidase-4 Inhibitors.
Tomovic K, Ilic BS, Smelcerovic A. Tomovic K, et al. J Med Chem. 2021 Jul 22;64(14):9639-9648. doi: 10.1021/acs.jmedchem.1c00293. Epub 2021 Jun 30. J Med Chem. 2021. PMID: 34190540 Review.
Approved and potent reported dipeptidyl peptidase-4 (DPP-4) inhibitors with gliptin-like structures are classified here according to their structures and mechanisms of the inhibition in three groups: (i) those with pyrrolidine or analogs as P1 fragment with alpha-aminoacyl …
Approved and potent reported dipeptidyl peptidase-4 (DPP-4) inhibitors with gliptin-like structures are classified here according to their s …
[60]fullerene-pyrrolidine-N-oxides.
Brough P, Klumpp C, Bianco A, Campidelli S, Prato M. Brough P, et al. J Org Chem. 2006 Mar 3;71(5):2014-20. doi: 10.1021/jo052388s. J Org Chem. 2006. PMID: 16496988
The reaction is very selective, favoring the nitrogen atom of the pyrrolidine ring in preference to epoxidation of the fullerene cage. ...Preliminary details of the effects of substitution on the reactivity of the pyrrolidine ring are also reported....
The reaction is very selective, favoring the nitrogen atom of the pyrrolidine ring in preference to epoxidation of the fullerene cage …
Biogenesis of nicotine.
GRIFFITH T, BYERRUM RU. GRIFFITH T, et al. Science. 1959 May 29;129(3361):1485-6. doi: 10.1126/science.129.3361.1485. Science. 1959. PMID: 13658978
When acetate-1-C(14) was administered to the plants the nicotine contained C(14) only in the pyrrolidine ring. After acetate-2-C(14) was fed, C(14) was located in both the pyrrolidine and pyridine rings....
When acetate-1-C(14) was administered to the plants the nicotine contained C(14) only in the pyrrolidine ring. After acetate-2-C(14) …
Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties.
Masila VM, Ndakala AJ, Midiwo JO, Byamukama R, Kamau RW, Kumarihamy M, Muhammad I. Masila VM, et al. Nat Prod Res. 2022 May;36(9):2321-2328. doi: 10.1080/14786419.2020.1833201. Epub 2020 Oct 24. Nat Prod Res. 2022. PMID: 33103456
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-pipe …
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivativ …
Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna.
Parks HM, Cinelli MA, Bedewitz MA, Grabar JM, Hurney SM, Walker KD, Jones AD, Barry CS. Parks HM, et al. New Phytol. 2023 Mar;237(5):1810-1825. doi: 10.1111/nph.18651. Epub 2022 Dec 18. New Phytol. 2023. PMID: 36451537 Free PMC article.
As such, many plant-specialized metabolic networks are poorly characterized. The N-methyl delta(1) -pyrrolinium cation is a simple pyrrolidine alkaloid and precursor of pharmacologically important tropane alkaloids. Silencing of pyrrolidine ketide synthase (AbPyKS) …
As such, many plant-specialized metabolic networks are poorly characterized. The N-methyl delta(1) -pyrrolinium cation is a simple pyrrol …
New directions in thermoresponsive polymers.
Roy D, Brooks WL, Sumerlin BS. Roy D, et al. Chem Soc Rev. 2013 Sep 7;42(17):7214-43. doi: 10.1039/c3cs35499g. Epub 2013 Feb 28. Chem Soc Rev. 2013. PMID: 23450220 Review.
81,913 results
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