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PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht LH, Black AR, Black JD. Pysz MA, et al. Exp Cell Res. 2009 May 1;315(8):1415-28. doi: 10.1016/j.yexcr.2009.02.002. Epub 2009 Feb 14. Exp Cell Res. 2009. PMID: 19232344 Free PMC article.
Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.
Guan L, Song K, Pysz MA, Curry KJ, Hizli AA, Danielpour D, Black AR, Black JD. Guan L, et al. J Biol Chem. 2007 May 11;282(19):14213-25. doi: 10.1074/jbc.M610513200. Epub 2007 Mar 13. J Biol Chem. 2007. PMID: 17360714
Vascular endothelial growth factor receptor type 2-targeted contrast-enhanced US of pancreatic cancer neovasculature in a genetically engineered mouse model: potential for earlier detection.
Pysz MA, Machtaler SB, Seeley ES, Lee JJ, Brentnall TA, Rosenberg J, Tranquart F, Willmann JK. Pysz MA, et al. Version 2. Radiology. 2015 Mar;274(3):790-9. doi: 10.1148/radiol.14140568. Epub 2014 Oct 14. Radiology. 2015. PMID: 25322341 Free PMC article.
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