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Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
Cui Y, Brosnan JA, Blackford AL, Sur S, Hruban RH, Kinzler KW, Vogelstein B, Maitra A, Diaz LA Jr, Iacobuzio-Donahue CA, Eshleman JR. Cui Y, et al. Clin Cancer Res. 2012 Dec 1;18(23):6519-30. doi: 10.1158/1078-0432.CCR-12-0827. Epub 2012 Jul 2. Clin Cancer Res. 2012. PMID: 22753594 Free PMC article.
PURPOSE: Pancreatic cancer is the fourth cause of death from cancer in the western world. ...Most pancreatic cancer cells were also sensitive to gemcitabine and MMC. ...
PURPOSE: Pancreatic cancer is the fourth cause of death from cancer in the western world. ...Most pancreatic
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR Jr, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, 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Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Extracellular vesicles in pancreatic cancer immune escape: Emerging roles and mechanisms.
Liu C, He D, Li L, Zhang S, Wang L, Fan Z, Wang Y. Liu C, et al. Pharmacol Res. 2022 Sep;183:106364. doi: 10.1016/j.phrs.2022.106364. Epub 2022 Jul 25. Pharmacol Res. 2022. PMID: 35901939 Review.
Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis and limited treatment options. ...This review aims to provide a better understanding of the roles of EVs in tumor immune escape and the potential to expand their application
Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis and limited treatment options. ...
Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities.
Djamgoz MBA, Jentzsch V. Djamgoz MBA, et al. Nutr Cancer. 2022;74(4):1139-1162. doi: 10.1080/01635581.2021.1934043. Epub 2021 Jun 4. Nutr Cancer. 2022. PMID: 34085871 Review.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. The standard first-line treatment for PDAC is gemcitabine chemotherapy which, unfortunately, offers only limited chance of a lasting cure. ...Two groups of complementary agents are considered: Dietary factor
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. The standard first-line treatment for PDAC is gemcitabine chemother
Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo.
Chen H, Sun B, Pan S, Jiang H, Sun X. Chen H, et al. Anticancer Drugs. 2009 Feb;20(2):131-40. doi: 10.1097/CAD.0b013e3283212ade. Anticancer Drugs. 2009. PMID: 19209030
Its effect on pancreatic cancer is, however, unknown and the mechanism is unclear. ...This study indicates that DHA may be a potent and promising agent to combat pancreatic cancer....
Its effect on pancreatic cancer is, however, unknown and the mechanism is unclear. ...This study indicates that DHA may be a p …
Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB.
Chen H, Sun B, Wang S, Pan S, Gao Y, Bai X, Xue D. Chen H, et al. J Cancer Res Clin Oncol. 2010 Jun;136(6):897-903. doi: 10.1007/s00432-009-0731-0. Epub 2009 Nov 26. J Cancer Res Clin Oncol. 2010. PMID: 19941148
PURPOSE: In a recent publication, we have shown that dihydroartemisinin (DHA), a derivative of antimalaria drug artemisinin, inhibits growth of pancreatic cancer cells in vitro and in vivo mediated by its anti-proliferative and pro-apoptotic effects. ...We su …
PURPOSE: In a recent publication, we have shown that dihydroartemisinin (DHA), a derivative of antimalaria drug artemisinin, inhibits …
Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo.
Du JH, Zhang HD, Ma ZJ, Ji KM. Du JH, et al. Cancer Chemother Pharmacol. 2010 Apr;65(5):895-902. doi: 10.1007/s00280-009-1095-5. Epub 2009 Aug 19. Cancer Chemother Pharmacol. 2010. PMID: 19690861 Free PMC article.
Pancreatic cancer is highly resistant to the currently available chemotherapeutic agents. ...Thus, there is an urgent need for the development of novel, efficacious drugs that can treat pancreatic cancer. Herein we report the identification of artesuna
Pancreatic cancer is highly resistant to the currently available chemotherapeutic agents. ...Thus, there is an urgent need for
Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.
Kong R, Jia G, Cheng ZX, Wang YW, Mu M, Wang SJ, Pan SH, Gao Y, Jiang HC, Dong DL, Sun B. Kong R, et al. PLoS One. 2012;7(5):e37222. doi: 10.1371/journal.pone.0037222. Epub 2012 May 30. PLoS One. 2012. PMID: 22666346 Free PMC article.
BACKGROUND: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various cancer cells. ...CONCLUSIONS/SIGNIFICANCE: These results suggest that DHA enhances Apo2L/TRAIL-mediated apoptosis in human pancreati
BACKGROUND: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various …
Cascade Catalytic Nanoplatform Based on "Butterfly Effect" for Enhanced Immunotherapy.
Shao Y, Wang Z, Hao Y, Zhang X, Wang N, Chen K, Chang J, Feng Q, Zhang Z. Shao Y, et al. Adv Healthc Mater. 2021 Apr;10(8):e2002171. doi: 10.1002/adhm.202002171. Epub 2021 Jan 14. Adv Healthc Mater. 2021. PMID: 33448146
The unique tumor microenvironment (TME) characteristics such as immunosuppression impeded traditional cancer treatments. In contrast, developing cascade catalytic nanoplatforms by fully making use of substances in TME for cancer therapy may deserve full credit. ...B …
The unique tumor microenvironment (TME) characteristics such as immunosuppression impeded traditional cancer treatments. In contrast, …
Anticancer activity of botanical compounds in ancient fermented beverages (review).
McGovern PE, Christofidou-Solomidou M, Wang W, Dukes F, Davidson T, El-Deiry WS. McGovern PE, et al. Int J Oncol. 2010 Jul;37(1):5-14. doi: 10.3892/ijo_00000647. Int J Oncol. 2010. PMID: 20514391 Review.
Humans around the globe probably discovered natural remedies against disease and cancer by trial and error over the millennia. Biomolecular archaeological analyses of ancient organics, especially plants dissolved or decocted as fermented beverages, have begun to reveal the …
Humans around the globe probably discovered natural remedies against disease and cancer by trial and error over the millennia. Biomol …
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