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Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Hsu CW, Zhao J, Huang R, Hsieh JH, Hamm J, Chang X, Houck K, Xia M. Hsu CW, et al. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437. Sci Rep. 2014. PMID: 25257666 Free PMC article.
The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. ...We used a cell-based human FXR beta-lactamase (Bla) reporter gene assay to profile the Tox21 10K compound collection of environmental chemicals
The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. ...We used a cell-based hu …
Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.
Hsu CW, Hsieh JH, Huang R, Pijnenburg D, Khuc T, Hamm J, Zhao J, Lynch C, van Beuningen R, Chang X, Houtman R, Xia M. Hsu CW, et al. Toxicol Appl Pharmacol. 2016 Dec 15;313:138-148. doi: 10.1016/j.taap.2016.10.017. Epub 2016 Oct 20. Toxicol Appl Pharmacol. 2016. PMID: 27773686 Free PMC article.
Chemicals that alter normal function of farnesoid X receptor (FXR) have been shown to affect the homeostasis of bile acids, glucose, and lipids. Several structural classes of environmental chemicals and drugs that modulated
Chemicals that alter normal function of farnesoid X receptor (FXR) have been shown to affect the homeostasis of
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