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Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea.
Kros CJ, Rüsch A, Richardson GP. Kros CJ, et al. Proc Biol Sci. 1992 Aug 22;249(1325):185-93. doi: 10.1098/rspb.1992.0102. Proc Biol Sci. 1992. PMID: 1280836
The hair bundles were stimulated by force from a fluid jet. The transducer currents in outer hair cells are the largest found so far in any hair cell, with a chord conductance of up to 9.2 nS at -84 mV. ...The permeabilities for sodium, potassium and caesium are sim …
The hair bundles were stimulated by force from a fluid jet. The transducer currents in outer hair cells are the largest found so far …
Sodium and calcium currents shape action potentials in immature mouse inner hair cells.
Marcotti W, Johnson SL, Rusch A, Kros CJ. Marcotti W, et al. J Physiol. 2003 Nov 1;552(Pt 3):743-61. doi: 10.1113/jphysiol.2003.043612. Epub 2003 Aug 22. J Physiol. 2003. PMID: 12937295 Free PMC article.
Only the Ca2+ current is necessary for spontaneous and induced action potentials, and 29 % of cells lacked a Na+ current. The Na+ current does, however, shorten the time to reach the action-potential threshold, whereas the Ca2+ current is mainly involved, together with the …
Only the Ca2+ current is necessary for spontaneous and induced action potentials, and 29 % of cells lacked a Na+ current. The Na+ cur …
Hair cells in mammalian utricles.
Eatock RA, Rüsch A, Lysakowski A, Saeki M. Eatock RA, et al. Otolaryngol Head Neck Surg. 1998 Sep;119(3):172-81. doi: 10.1016/S0194-5998(98)70052-X. Otolaryngol Head Neck Surg. 1998. PMID: 9743073 Review.
Understanding the functional significance of these strikingly different morphological features has proved to be a challenge. Experiments that correlated the response properties of primary vestibular afferents with the morphologies of their afferent terminals suggested that …
Understanding the functional significance of these strikingly different morphological features has proved to be a challenge. Experime …
Postnatal development of type I and type II hair cells in the mouse utricle: acquisition of voltage-gated conductances and differentiated morphology.
Rüsch A, Lysakowski A, Eatock RA. Rüsch A, et al. J Neurosci. 1998 Sep 15;18(18):7487-501. doi: 10.1523/JNEUROSCI.18-18-07487.1998. J Neurosci. 1998. PMID: 9736667 Free PMC article.
From postnatal day 1 (P1) to P3, most hair cells expressed a delayed rectifier that activated positive to resting potential and a fast inward rectifier, gK1. Between P4 and P8, many cells acquired the type I-specific conductance gK,L and/or a slow inward rect …
From postnatal day 1 (P1) to P3, most hair cells expressed a delayed rectifier that activated positive to resting potential and a
Expression of a potassium current in inner hair cells during development of hearing in mice.
Kros CJ, Ruppersberg JP, Rüsch A. Kros CJ, et al. Nature. 1998 Jul 16;394(6690):281-4. doi: 10.1038/28401. Nature. 1998. PMID: 9685158
During development, these demands may alter considerably, often associated with a change in the cells' complement of ion channels. ...This change in potassium channel expression turns the inner hair cell from a regenerative, spiking pacemaker into a high-freq …
During development, these demands may alter considerably, often associated with a change in the cells' complement of ion channels. .. …
Mechanically and ATP-induced currents of mouse outer hair cells are independent and differentially blocked by d-tubocurarine.
Glowatzki E, Ruppersberg JP, Zenner HP, Rüsch A. Glowatzki E, et al. Neuropharmacology. 1997 Sep;36(9):1269-75. doi: 10.1016/s0028-3908(97)00108-1. Neuropharmacology. 1997. PMID: 9364481
Using whole-cell patch-clamp recordings of outer hair cells (OHCs) of the cultured neonatal mouse cochlea and a fluid jet to stimulate their hair bundles mechanically, we show that d-tubocurarine, a blocker of P2X2 receptors, blocks MET channels with a half-b …
Using whole-cell patch-clamp recordings of outer hair cells (OHCs) of the cultured neonatal mouse cochlea and a fluid jet to stimulat …
A delayed rectifier conductance in type I hair cells of the mouse utricle.
Rüsch A, Eatock RA. Rüsch A, et al. J Neurophysiol. 1996 Aug;76(2):995-1004. doi: 10.1152/jn.1996.76.2.995. J Neurophysiol. 1996. PMID: 8871214
The kinetic data of gK,L are consistent with a sequential gating model with at least two closed states and one open state. The slow activation kinetics (principal time constants at 23-25 degrees C:600-200 ms) had a thermal Q10 of 2.1. ...Deactivation followed a
The kinetic data of gK,L are consistent with a sequential gating model with at least two closed states and one open state. The slow a …
Voltage responses of mouse utricular hair cells to injected currents.
Rüsch A, Eatock RA. Rüsch A, et al. Ann N Y Acad Sci. 1996 Jun 19;781:71-84. doi: 10.1111/j.1749-6632.1996.tb15694.x. Ann N Y Acad Sci. 1996. PMID: 8694485 No abstract available.
Block by amiloride and its derivatives of mechano-electrical transduction in outer hair cells of mouse cochlear cultures.
Rüsch A, Kros CJ, Richardson GP. Rüsch A, et al. J Physiol. 1994 Jan 1;474(1):75-86. doi: 10.1113/jphysiol.1994.sp020004. J Physiol. 1994. PMID: 7516972 Free PMC article.
The form of the voltage dependence is consistent with a voltage-independent binding of the drug to a site that is accessible at hyperpolarized but not at depolarized potentials, suggesting that the transducer channel undergoes a voltage-dependent conformation …
The form of the voltage dependence is consistent with a voltage-independent binding of the drug to a site that is accessible a …
Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing.
Rüsch A, Erway LC, Oliver D, Vennström B, Forrest D. Rüsch A, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15758-62. doi: 10.1073/pnas.95.26.15758. Proc Natl Acad Sci U S A. 1998. PMID: 9861043 Free PMC article.
Here, TRalpha1-deficient (TRalpha1(-/-)) mice are shown to display a normal auditory-evoked brainstem response, indicating that only TRbeta, and not TRalpha1, is essential for hearing. ...At the onset of hearing, inner hair cells (IHCs) in wild-type mice express a f …
Here, TRalpha1-deficient (TRalpha1(-/-)) mice are shown to display a normal auditory-evoked brainstem response, indicating that only …
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