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Biologic activities of growth hormone secretagogues in humans.
Ghigo E, Arvat E, Giordano R, Broglio F, Gianotti L, Maccario M, Bisi G, Graziani A, Papotti M, Muccioli G, Deghenghi R, Camanni F. Ghigo E, et al. Among authors: deghenghi r. Endocrine. 2001 Feb;14(1):87-93. doi: 10.1385/ENDO:14:1:087. Endocrine. 2001. PMID: 11322506 Review.
GHSs release GH via actions on specific receptors (GHS-R) at the pituitary and, mainly, at the hypothalamic levels. GHSs likely act as functional somatostatin antagonists and meantime enhance the activity of GH-releasing hormone (GHRH)-secreting neurons. ...In physiologica …
GHSs release GH via actions on specific receptors (GHS-R) at the pituitary and, mainly, at the hypothalamic levels. GHSs likely act a …
Targeting the ghrelin receptor: orally active GHS and cortistatin analogs.
Deghenghi R, Broglio F, Papotti M, Muccioli G, Ghigo E. Deghenghi R, et al. Endocrine. 2003 Oct;22(1):13-8. doi: 10.1385/ENDO:22:1:13. Endocrine. 2003. PMID: 14610294 Review.
Based on these data, particular effort has been focused on the isolation of new putative natural ligands of the GHS-receptors (GHS-R) and on the identification of synthetic compounds endowed with agonistic or antagonistic activity. ...In this context, EP1572, a selective, …
Based on these data, particular effort has been focused on the isolation of new putative natural ligands of the GHS-receptors (GHS-R) …
New active series of growth hormone secretagogues.
Guerlavais V, Boeglin D, Mousseaux D, Oiry C, Heitz A, Deghenghi R, Locatelli V, Torsello A, Ghé C, Catapano F, Muccioli G, Galleyrand JC, Fehrentz JA, Martinez J. Guerlavais V, et al. Among authors: deghenghi r. J Med Chem. 2003 Mar 27;46(7):1191-203. doi: 10.1021/jm020985q. J Med Chem. 2003. PMID: 12646029
Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(d)-Trp-(d) …
Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in …
Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.
Sibilia V, Muccioli G, Deghenghi R, Pagani F, De Luca V, Rapetti D, Locatelli V, Netti C. Sibilia V, et al. Among authors: deghenghi r. J Neuroendocrinol. 2006 Feb;18(2):122-8. doi: 10.1111/j.1365-2826.2005.01391.x. J Neuroendocrinol. 2006. PMID: 16420281
Ghrelin, the endogenous ligand of the GH secretagogue receptor (GHS-R) has been previously shown to inhibit gastric acid secretion in pylorus-ligated rats. Two isoforms of GHS-R have been identified: GHS-R(1a) and GHS-R(1b). The present study aimed: (i …
Ghrelin, the endogenous ligand of the GH secretagogue receptor (GHS-R) has been previously shown to inhibit gastric acid secretion in …
Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans.
Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E. Arvat E, et al. Among authors: deghenghi r. J Endocrinol Invest. 2000 Sep;23(8):493-5. doi: 10.1007/BF03343763. J Endocrinol Invest. 2000. PMID: 11021763
An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently purified from rat and human stomach and named Ghrelin. It has been demonstrated that Ghrelin specifically stimulates GH secretion from rat pituitary cells in culture as well as in rats in vivo. …
An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently purified from rat and human stomach and named Ghrelin …
Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors.
Volante M, Allìa E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, Muccioli G, Ghigo E, Papotti M. Volante M, et al. Among authors: deghenghi r. J Clin Endocrinol Metab. 2002 Mar;87(3):1300-8. doi: 10.1210/jcem.87.3.8279. J Clin Endocrinol Metab. 2002. PMID: 11889202
It binds to the GH secretagogue receptor (GHS-R), which is present in a wide variety of central and peripheral human tissues. The aim of the present study was 2-fold: 1) to determine, by immunohistochemistry and mRNA analysis, whether pancreatic islet cells produce ghrelin …
It binds to the GH secretagogue receptor (GHS-R), which is present in a wide variety of central and peripheral human tissues. The aim …
Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans.
Broglio F, Koetsveld Pv Pv, Benso A, Gottero C, Prodam F, Papotti M, Muccioli G, Gauna C, Hofland L, Deghenghi R, Arvat E, Van Der Lely AJ, Ghigo E. Broglio F, et al. Among authors: deghenghi r. J Clin Endocrinol Metab. 2002 Oct;87(10):4829-32. doi: 10.1210/jc.2002-020956. J Clin Endocrinol Metab. 2002. PMID: 12364482 Clinical Trial.
Ghrelin possesses endocrine and non-endocrine actions mediated by the GH Secretagogue (GHS)-Receptors (GHS-R). The regulation of ghrelin secretion is still largely unknown. Somatostatin (SRIF) modulates central and gastroenteropancreatic hormonal secretions and functions. …
Ghrelin possesses endocrine and non-endocrine actions mediated by the GH Secretagogue (GHS)-Receptors (GHS-R). The regulation of ghre …
Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.
Muccioli G, Papotti M, Locatelli V, Ghigo E, Deghenghi R. Muccioli G, et al. Among authors: deghenghi r. J Endocrinol Invest. 2001 Mar;24(3):RC7-9. doi: 10.1007/BF03343831. J Endocrinol Invest. 2001. PMID: 11314756
Ghrelin has been proposed as a natural ligand of the GH secretagogue receptor(s) (GHS-R), which was an orphan receptor activated by synthetic peptidyl (hexarelin) and non-peptidyl (MK-0677) GHS to strongly release GH in animals and humans. ...
Ghrelin has been proposed as a natural ligand of the GH secretagogue receptor(s) (GHS-R), which was an orphan receptor activated by s …
Cortistatin-14 inhibits cell proliferation of human thyroid carcinoma cell lines of both follicular and parafollicular origin.
Cassoni P, Muccioli G, Marrocco T, Volante M, Allia E, Ghigo E, Deghenghi R, Papotti M. Cassoni P, et al. Among authors: deghenghi r. J Endocrinol Invest. 2002 Apr;25(4):362-8. doi: 10.1007/BF03344019. J Endocrinol Invest. 2002. PMID: 12030609
Addition of EP-80874 (D-Mrp-c[D-Cyspyridilalanyl3-D-Trp-Lys-Val-Cys]-Mrp-NH2), a synthetic peptide that binds to SRIH and GHS-R, completely abolished the antiproliferative effects of CST-14 or SRIH-14 on sst/GHS-R positive thyroid carcinoma cell lines (WRO, N-PAP an …
Addition of EP-80874 (D-Mrp-c[D-Cyspyridilalanyl3-D-Trp-Lys-Val-Cys]-Mrp-NH2), a synthetic peptide that binds to SRIH and GHS-R, comp …
Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland.
Deghenghi R, Papotti M, Ghigo E, Muccioli G. Deghenghi R, et al. J Endocrinol Invest. 2001 Jan;24(1):RC1-3. doi: 10.1007/BF03343800. J Endocrinol Invest. 2001. PMID: 11227737
Antagonism between GH secretagogues (GHS) and somatostatin (SRIH) has been postulated and demonstrated, but SRIH does not bind to GHS receptors (GHS-R) and potent synthetic peptidyl GHS (GHRP6, hexarelin) do not displace radiolabeled SRIH from its receptors. ...Our data de …
Antagonism between GH secretagogues (GHS) and somatostatin (SRIH) has been postulated and demonstrated, but SRIH does not bind to GHS recept …
23 results