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45 results

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Page 1
Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid.
Lechner S, Steimbach RR, Wang L, Deline ML, Chang YC, Fromme T, Klingenspor M, Matthias P, Miller AK, Médard G, Kuster B. Lechner S, et al. Nat Commun. 2023 Jun 15;14(1):3548. doi: 10.1038/s41467-023-39151-8. Nat Commun. 2023. PMID: 37322067 Free PMC article.
Lipoic acid is an essential enzyme cofactor in central metabolic pathways. ...Importantly, only the naturally occurring (R)-enantiomer inhibits HDACs at physiologically relevant concentrations and leads to hyperacetylation of HDAC substrates. The inhibition of HDACs by ( …
Lipoic acid is an essential enzyme cofactor in central metabolic pathways. ...Importantly, only the naturally occurring (R)-enantiome …
R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.
Korotchkina LG, Sidhu S, Patel MS. Korotchkina LG, et al. Free Radic Res. 2004 Oct;38(10):1083-92. doi: 10.1080/10715760400004168. Free Radic Res. 2004. PMID: 15512796
R-lipoic acid, S-lipoic acid and R-dihydrolipoic acid did not significantly affect activities of PDPs and at the same time inhibited PDKs to different extents (PDK1>PDK4 approximately PDK2>PDK3 for R-LA). ...R-lipoic acid …
R-lipoic acid, S-lipoic acid and R-dihydrolipoic acid did not significantly affect activities of PDPs and …
Cross-linked (R)-(+)-lipoic acid nanoparticles with prodrug loading for synergistic cancer therapy.
Yang F, Chen Y, Zhang J, Liao C, Zhang S. Yang F, et al. J Mater Chem B. 2021 Feb 14;9(6):1583-1591. doi: 10.1039/d0tb02425b. Epub 2021 Jan 20. J Mater Chem B. 2021. PMID: 33471011
Herein, we developed a new nanodrug 3-(methylthio)-propanoate camptothecin (Pro-CPT) loaded with cross-linked (R)-(+)-lipoic acid nanoparticles (Pro-CPT@cLANs). The Pro-CPT is a pH-responsive prodrug of camptothecin (CPT) that can effectively reduce the syste …
Herein, we developed a new nanodrug 3-(methylthio)-propanoate camptothecin (Pro-CPT) loaded with cross-linked (R)-(+)-lipoic …
Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism.
Watson PR, Stollmaier JG, Christianson DW. Watson PR, et al. J Biol Chem. 2023 Oct;299(10):105228. doi: 10.1016/j.jbc.2023.105228. Epub 2023 Sep 12. J Biol Chem. 2023. PMID: 37703993 Free PMC article.
The enzyme cofactor (R)-lipoic acid plays a critical role in central carbon metabolism due to its catalytic function in the generation of acetyl-CoA, which links glycolysis with the tricarboxylic acid cycle. ...Most recently, the reduced form of (R …
The enzyme cofactor (R)-lipoic acid plays a critical role in central carbon metabolism due to its catalytic function in …
Crystal Structure of Histone Deacetylase 6 Complexed with ( R )-Lipoic Acid, an Essential Cofactor in Central Carbon Metabolism.
Watson PR, Stollmaier JG, Christianson DW. Watson PR, et al. bioRxiv [Preprint]. 2023 Aug 9:2023.08.08.552419. doi: 10.1101/2023.08.08.552419. bioRxiv. 2023. PMID: 37609266 Free PMC article. Updated. Preprint.
The enzyme cofactor ( R )-lipoic acid plays a critical role in central carbon metabolism due to its catalytic function in the generation of acetyl-CoA, which links glycolysis with the tricarboxylic acid cycle. ...Most recently, the reduced form of ( …
The enzyme cofactor ( R )-lipoic acid plays a critical role in central carbon metabolism due to its catalytic function …
R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy.
Liu J, Song Q, Huang Y, Sun W, Lu D, Zhou B. Liu J, et al. Platelets. 2018 Nov;29(7):695-701. doi: 10.1080/09537104.2017.1356450. Epub 2017 Oct 6. Platelets. 2018. PMID: 28984160
R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. ...
R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been repo …
Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria.
Chen B, Foo JL, Ling H, Chang MW. Chen B, et al. Front Bioeng Biotechnol. 2020 Aug 20;8:965. doi: 10.3389/fbioe.2020.00965. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32974306 Free PMC article.
Toward sustainable production of R-lipoic acid, we aim to develop a synthetic biology-based method using engineered yeast. ...We then characterized in vitro the activity of a lipoamidase from Enterococcus faecalis for releasing free R-lipoic …
Toward sustainable production of R-lipoic acid, we aim to develop a synthetic biology-based method using engineered yea …
[Lipoic acid: physiological role and prospects for clinical application].
Tutelyan VA, Makhova AA, Pogozheva AV, Shikh EV, Elizarova EV, Khotimchenko SA. Tutelyan VA, et al. Vopr Pitan. 2019;88(4):6-11. doi: 10.24411/0042-8833-2019-10035. Epub 2019 Jul 15. Vopr Pitan. 2019. PMID: 31722135 Review. Russian.
Lipoic acid contains asymmetrical carbon, which causes the presence of two possible optical isomers (enantiomers): R-lipoic acid (levogyrate isomer) and S-lipoic acid (rightspinning isomer). ...Lipoic acid can be used to control body weig …
Lipoic acid contains asymmetrical carbon, which causes the presence of two possible optical isomers (enantiomers): R-lipoic …
Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial.
Cameron M, Taylor C, Lapidus J, Ramsey K, Koop D, Spain R. Cameron M, et al. J Clin Pharmacol. 2020 Aug;60(8):1099-1106. doi: 10.1002/jcph.1605. Epub 2020 Mar 25. J Clin Pharmacol. 2020. PMID: 32212340 Clinical Trial.
We compared the gastrointestinal (GI) tolerability and assessed for bioequivalent absorption of R-lipoic acid (LA) in people with progressive multiple sclerosis (MS) in a single-center, double-blind, randomized crossover trial. ...
We compared the gastrointestinal (GI) tolerability and assessed for bioequivalent absorption of R-lipoic acid (LA) in p …
Quaternary Ammonium Salts Anchored on Cross-Linked (R)-(+)-Lipoic Acid Nanoparticles for Drug-Resistant Tumor Therapy.
Zhou X, Dai X, Tan J, Wu X, Zhou X, Liao C, Zhang S. Zhou X, et al. ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56850-56857. doi: 10.1021/acsami.1c16293. Epub 2021 Nov 29. ACS Appl Mater Interfaces. 2021. PMID: 34844408
A membrane-lytic mechanism-based nanodrug is developed for drug-resistant tumor therapy by anchoring the small-molecule quaternary ammonium salt (QAS) on cross-linked (R)-(+)-lipoic acid nanoparticles (cLANs). The anchoring of QAS on the nanoparticle avoids t …
A membrane-lytic mechanism-based nanodrug is developed for drug-resistant tumor therapy by anchoring the small-molecule quaternary ammonium …
45 results