R01 AA018123/AA/NIAAA NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
1994	1
2010	2
2011	2
2012	1
2013	2
2014	6
2015	5
2017	1
2018	1
2022	0

1

Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application.

Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Koppaka V, et al. Pharmacol Rev. 2012 Jul;64(3):520-39. doi: 10.1124/pr.111.005538. Epub 2012 Apr 27. Pharmacol Rev. 2012. PMID: 22544865 Free PMC article. Review.

2

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH^High Melanoma-Initiating Cells.

Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE. Sarvi S, et al. Cell Chem Biol. 2018 Dec 20;25(12):1456-1469.e6. doi: 10.1016/j.chembiol.2018.09.005. Epub 2018 Oct 4. Cell Chem Biol. 2018. PMID: 30293938 Free PMC article.

3

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.

Buchman CD, Mahalingan KK, Hurley TD. Buchman CD, et al. Chem Biol Interact. 2015 Jun 5;234:38-44. doi: 10.1016/j.cbi.2014.12.038. Epub 2015 Jan 29. Chem Biol Interact. 2015. PMID: 25641190 Free PMC article.

4

β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.

Condello S, Morgan CA, Nagdas S, Cao L, Turek J, Hurley TD, Matei D. Condello S, et al. Oncogene. 2015 Apr 30;34(18):2297-308. doi: 10.1038/onc.2014.178. Epub 2014 Jun 23. Oncogene. 2015. PMID: 24954508 Free PMC article.

5

Catalytic contribution of threonine 244 in human ALDH2.

González-Segura L, Ho KK, Perez-Miller S, Weiner H, Hurley TD. González-Segura L, et al. Chem Biol Interact. 2013 Feb 25;202(1-3):32-40. doi: 10.1016/j.cbi.2012.12.009. Epub 2013 Jan 4. Chem Biol Interact. 2013. PMID: 23295226 Free PMC article.

6

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.

Buchman CD, Hurley TD. Buchman CD, et al. J Med Chem. 2017 Mar 23;60(6):2439-2455. doi: 10.1021/acs.jmedchem.6b01825. Epub 2017 Mar 6. J Med Chem. 2017. PMID: 28219011 Free PMC article.

7

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes.

Parajuli B, Kimble-Hill AC, Khanna M, Ivanova Y, Meroueh S, Hurley TD. Parajuli B, et al. Chem Biol Interact. 2011 May 30;191(1-3):153-8. doi: 10.1016/j.cbi.2011.02.018. Epub 2011 Feb 22. Chem Biol Interact. 2011. PMID: 21349255 Free PMC article.

8

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

Morgan CA, Parajuli B, Buchman CD, Dria K, Hurley TD. Morgan CA, et al. Chem Biol Interact. 2015 Jun 5;234:18-28. doi: 10.1016/j.cbi.2014.12.008. Epub 2014 Dec 12. Chem Biol Interact. 2015. PMID: 25512087 Free PMC article.

9

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.

Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD. Kimble-Hill AC, et al. J Med Chem. 2014 Feb 13;57(3):714-22. doi: 10.1021/jm401377v. Epub 2014 Jan 31. J Med Chem. 2014. PMID: 24444054 Free PMC article.

10

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.

Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD. Khanna M, et al. J Biol Chem. 2011 Dec 16;286(50):43486-94. doi: 10.1074/jbc.M111.293597. Epub 2011 Oct 21. J Biol Chem. 2011. PMID: 22021038 Free PMC article.

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