Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Affiliations

• ¹ Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.
• ² Genometrics Section, Computational and Statistical Genomics Branch, Division of Intramural Research, National Human Genome Research Institute, US National Institutes of Health (NIH), Baltimore, MD, 21224, USA.
• ³ Key Laboratory of Brain Function and Disease, School of Life Sciences, Chinese Academy of Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China.
• ⁴ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
• ⁵ Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
• ⁶ Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
• ⁷ Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA.
• ⁸ Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
• ⁹ Institute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
• ¹⁰ Department of Integrative Physiology, University of Colorado, Boulder, CO, 80309, USA.
• ¹¹ Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA.
• ¹² Department of Psychiatry, Universitätsklinikum Halle (Saale), 06112, Halle (Saale), Germany.
• ¹³ Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
• ¹⁴ Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.
• ¹⁵ Department of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
• ¹⁶ Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA.
• ¹⁷ Oregon Research Institute, Eugene, OR, 97403, USA.
• ¹⁸ Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
• ¹⁹ Section of Human Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892, USA.
• ²⁰ Department of Psychiatry, Yale University, New Haven, CT, 06516, USA.
• ²¹ Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, United Kingdom.
• ²² Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, 1431, Sofia, Bulgaria.
• ²³ Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
• ²⁴ Department. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
• ²⁵ Division of Medical Genetics, Department of Biomedicine, University Hospital Basel, University of Basel, Basel, 4003, Switzerland.
• ²⁶ Ökumenisches Hainich-Klinikum, Mühlhausen/Thüringen, Germany.
• ²⁷ National Drug and Alcohol Research Centre, University of New South Wales, Randwick, NSW, 2031, Australia.
• ²⁸ School of Population and Global Health, University of Melbourne, Melbourne, 3010, Australia.
• ²⁹ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
• ³⁰ University of Düsseldorf, 40225, Düsseldorf, Germany.
• ³¹ Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
• ³² Center for Health Sciences, Biosciences Division, SRI International, Menlo Park, CA, 94025, USA.
• ³³ Institute of Behavioral Science, University of Colorado, Boulder, CO, 80309, USA.
• ³⁴ Max-Planck-Institute of Psychiatry, 80804, Munich, Germany.
• ³⁵ Behavioral Health Research Division, Research Triangle Institute International, Durham, NC, 27709, USA.
• ³⁶ Department of Oncology, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
• ³⁷ Department of Addictive Behavior and Addiction Medicine, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
• ³⁸ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
• ³⁹ Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, 80309, USA.
• ⁴⁰ Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, 10065, USA.
• ⁴¹ Addictions Department, Institute of Psychiatry, King's College London, London, SE5 8BB, UK.
• ⁴² University of Bonn, 53113, Bonn, Germany.
• ⁴³ Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
• ⁴⁴ Department of Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, 4029, Australia.
• ⁴⁵ Harvard School of Public Health, Boston, MA, 02115, USA.
• ⁴⁶ Aarhus University, Aarhus, 8000, Denmark.
• ⁴⁷ Childhood Cancer Research Group, University of Oxford, Oxford, OX3 7LG, UK.
• ⁴⁸ Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
• ⁴⁹ Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
• ⁵⁰ Department of Psychiatry, University Medical Center Regensburg, University of Regensburg, 8548, Regensburg, Germany.
• ⁵¹ Psychiatric Hospital, Konigsfelden, Windisch, Switzerland.
• ⁵² Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
• ⁵³ Addiction Research Group at the Department of Psychiatry and Psychotherapy, LVR Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
• ⁵⁴ Department of Psychiatry, University of Munich, 3860, Munich, Germany.
• ⁵⁵ Private Hospital Meiringen, Meiringen, Switzerland.
• ⁵⁶ Department of Psychology & Neuroscience, University of Colorado, Boulder, CO, 80309, USA.
• ⁵⁷ Research Department, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.
• ⁵⁸ University of Munich, Munich, Germany.
• ⁵⁹ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
• ⁶⁰ Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
• ⁶¹ Department of Genetics, Yale University, New Haven, CT, 06516, USA.
• ⁶² Department of Neurobiology, Yale University, New Haven, CT, 06516, USA.
• ⁶³ Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
• ⁶⁴ Institute for Molecular Medicine FIMM, University of Helsinki, 00014, Helsinki, Finland.
• ⁶⁵ MRC Integrative Epidemiology Unit, UK Centre for Tobacco and Alcohol Studies, and School of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, UK.
• ⁶⁶ Department of Psychiatry, University of Iowa, Iowa City, IA, 52242, USA.
• ⁶⁷ Psychiatry Service, Department of Veteran Affairs, New Jersey VA Health Care System, East Orange, NJ, 07018, USA.
• ⁶⁸ Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, 94304, USA.
• ⁶⁹ Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
• ⁷⁰ Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA. nlims@genetics.wustl.edu.