R01 AG017574/AG/NIA NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2002	1
2005	3
2006	1
2008	2
2009	1
2010	1
2011	2
2021	0

1

Intramembrane proteolysis.

Wolfe MS. Wolfe MS. Chem Rev. 2009 Apr;109(4):1599-612. doi: 10.1021/cr8004197. Chem Rev. 2009. PMID: 19226105 Free PMC article. Review. No abstract available.

2

Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.

Wolfe MS. Wolfe MS. Biol Chem. 2010 Aug;391(8):839-47. doi: 10.1515/BC.2010.086. Biol Chem. 2010. PMID: 20482315 Free PMC article. Review.

3

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

4

Inhibition and modulation of gamma-secretase for Alzheimer's disease.

Wolfe MS. Wolfe MS. Neurotherapeutics. 2008 Jul;5(3):391-8. doi: 10.1016/j.nurt.2008.05.010. Neurotherapeutics. 2008. PMID: 18625450 Free PMC article. Review.

5

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS. Quintero-Monzon O, et al. Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30. Biochemistry. 2011. PMID: 21919498 Free PMC article.

6

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.

Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Hong S, et al. J Neurosci. 2011 Nov 2;31(44):15861-9. doi: 10.1523/JNEUROSCI.3272-11.2011. J Neurosci. 2011. PMID: 22049429 Free PMC article.

7

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.

Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS. Fraering PC, et al. J Biol Chem. 2005 Dec 23;280(51):41987-96. doi: 10.1074/jbc.M501368200. Epub 2005 Oct 19. J Biol Chem. 2005. PMID: 16236717 Free PMC article.

8

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.

Kornilova AY, Bihel F, Das C, Wolfe MS. Kornilova AY, et al. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3230-5. doi: 10.1073/pnas.0407640102. Epub 2005 Feb 18. Proc Natl Acad Sci U S A. 2005. PMID: 15722417 Free PMC article.

9

Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity.

Urban S, Wolfe MS. Urban S, et al. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1883-8. doi: 10.1073/pnas.0408306102. Epub 2005 Jan 31. Proc Natl Acad Sci U S A. 2005. PMID: 15684070 Free PMC article.

10

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Esler WP, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. doi: 10.1073/pnas.052436599. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867728 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

Search Page

Search Results