Abstract
Muscle weakness ensues when serum testosterone declines with age in men. Testosterone's female counterpart, estrogen, also has been implicated in age-related strength loss, but these results are less conclusive. Our working hypothesis is that estrogens do benefit muscle strength, and that the underlying mechanism involves estrogen receptors to improve muscle quality more so than quantity.
Publication types
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Meta-Analysis
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / physiology*
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Animals
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Electron Spin Resonance Spectroscopy
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Estradiol / physiology
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Estrogens / physiology*
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Female
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Humans
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Menopause / physiology
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Mice
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Muscle Strength / physiology*
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Muscle Weakness
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Muscle, Skeletal / metabolism
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Myosins / physiology
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Myosins / ultrastructure
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Rats
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Receptors, Estrogen / metabolism
Substances
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Estrogens
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Receptors, Estrogen
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Estradiol
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Myosins