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Mitochondrial ROS signaling in organismal homeostasis.

Shadel GS, Horvath TL. Shadel GS, et al. Cell. 2015 Oct 22;163(3):560-9. doi: 10.1016/j.cell.2015.10.001. Epub 2015 Oct 22. Cell. 2015. PMID: 26496603 Free PMC article. Review.

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Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. West AP, et al. Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2. Nature. 2015. PMID: 25642965 Free PMC article.

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Mitochondrial DNA in innate immune responses and inflammatory pathology.

West AP, Shadel GS. West AP, et al. Nat Rev Immunol. 2017 Jun;17(6):363-375. doi: 10.1038/nri.2017.21. Epub 2017 Apr 10. Nat Rev Immunol. 2017. PMID: 28393922 Free PMC article. Review.

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Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Rongvaux A, et al. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. Cell. 2014. PMID: 25525875 Free PMC article.

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A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis.

Kang MJ, Shadel GS. Kang MJ, et al. Tuberc Respir Dis (Seoul). 2016 Oct;79(4):207-213. doi: 10.4046/trd.2016.79.4.207. Epub 2016 Oct 5. Tuberc Respir Dis (Seoul). 2016. PMID: 27790272 Free PMC article. Review.

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Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson-Gilford progeria syndrome.

Murtada SI, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD. Murtada SI, et al. J R Soc Interface. 2020 May;17(166):20200066. doi: 10.1098/rsif.2020.0066. Epub 2020 May 27. J R Soc Interface. 2020. PMID: 32453981

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Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.

Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE. Schweppe DK, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1732-1737. doi: 10.1073/pnas.1617220114. Epub 2017 Jan 27. Proc Natl Acad Sci U S A. 2017. PMID: 28130547 Free PMC article.

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Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS. Zhang Y, et al. Sci Signal. 2018 Jul 10;11(538):eaaq0702. doi: 10.1126/scisignal.aaq0702. Sci Signal. 2018. PMID: 29991649 Free PMC article.

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Suppression of NLRX1 in chronic obstructive pulmonary disease.

Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Kang MJ, et al. J Clin Invest. 2015 Jun;125(6):2458-62. doi: 10.1172/JCI71747. Epub 2015 May 4. J Clin Invest. 2015. PMID: 25938787 Free PMC article. Clinical Trial.

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MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.

Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. Mannam P, et al. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L604-19. doi: 10.1152/ajplung.00272.2013. Epub 2014 Jan 31. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24487387 Free PMC article.

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