Influenza neuraminidase

Influenza Other Respir Viruses. 2012 Jul;6(4):245-56. doi: 10.1111/j.1750-2659.2011.00304.x. Epub 2011 Nov 16.

Abstract

Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antiviral Agents / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Influenza Vaccines / immunology
  • Models, Molecular
  • Neuraminidase / antagonists & inhibitors
  • Neuraminidase / chemistry*
  • Neuraminidase / immunology
  • Neuraminidase / metabolism*
  • Orthomyxoviridae / drug effects
  • Orthomyxoviridae / enzymology*
  • Protein Conformation
  • Viral Proteins / antagonists & inhibitors
  • Viral Proteins / chemistry*
  • Viral Proteins / immunology
  • Viral Proteins / metabolism*

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • Influenza Vaccines
  • Viral Proteins
  • Neuraminidase