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Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation.
Williams LM, Inge MM, Mansfield KM, Rasmussen A, Afghani J, Agrba M, Albert C, Andersson C, Babaei M, Babaei M, Bagdasaryants A, Bonilla A, Browne A, Carpenter S, Chen T, Christie B, Cyr A, Dam K, Dulock N, Erdene G, Esau L, Esonwune S, Hanchate A, Huang X, Jennings T, Kasabwala A, Kehoe L, Kobayashi R, Lee M, LeVan A, Liu Y, Murphy E, Nambiar A, Olive M, Patel D, Pavesi F, Petty CA, Samofalova Y, Sanchez S, Stejskal C, Tang Y, Yapo A, Cleary JP Jr, Yunes SA, Siggers T, Gilmore TD. Williams LM, et al. Dev Comp Immunol. 2020 Mar;104:103559. doi: 10.1016/j.dci.2019.103559. Epub 2019 Nov 18. Dev Comp Immunol. 2020. PMID: 31751628
Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system.
Bruno L, Ramlall V, Studer RA, Sauer S, Bradley D, Dharmalingam G, Carroll T, Ghoneim M, Chopin M, Nutt SL, Elderkin S, Rueda DS, Fisher AG, Siggers T, Beltrao P, Merkenschlager M. Bruno L, et al. Nat Immunol. 2019 Oct;20(10):1372-1380. doi: 10.1038/s41590-019-0471-5. Epub 2019 Aug 26. Nat Immunol. 2019. PMID: 31451789 Free PMC article.