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A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism.
J Biol Chem. 2013 Sep 13;288(37):26635-48. doi: 10.1074/jbc.M113.495770. Epub 2013 Jul 31.
J Biol Chem. 2013.
PMID: 23902773
Free PMC article.
Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.
Silva F, Hummel AM, Jenne DE, Specks U.
Silva F, et al.
J Autoimmun. 2010 Dec;35(4):299-308. doi: 10.1016/j.jaut.2010.06.021.
J Autoimmun. 2010.
PMID: 20810247
Free PMC article.
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Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis.
Finkielman JD, Merkel PA, Schroeder D, Hoffman GS, Spiera R, St Clair EW, Davis JC Jr, McCune WJ, Lears A, Ytterberg SR, Hummel AM, Viss MA, Peikert T, Stone JH, Specks U; WGET Research Group.
Finkielman JD, et al.
Clin Exp Rheumatol. 2009 Jan-Feb;27(1 Suppl 52):S45-52.
Clin Exp Rheumatol. 2009.
PMID: 19646346
Free PMC article.
Clinical Trial.
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Agreement of anti-neutrophil cytoplasmic antibody measurements obtained from serum and plasma.
Lee AS, Finkielman JD, Peikert T, Hummel AM, Viss MA, Jacob GL, Homburger HA, Specks U; Wegener's Granulomatosis Etanercept Trial Research Group.
Lee AS, et al.
Clin Exp Immunol. 2006 Oct;146(1):15-20. doi: 10.1111/j.1365-2249.2006.03179.x.
Clin Exp Immunol. 2006.
PMID: 16968393
Free PMC article.
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