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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria
Cárdenas C, et al. Cell 2010. PMID 20655468 Free PMC article.
Here we identified an unexpected and essential role for constitutive InsP(3)R-mediated Ca(2+) release in maintaining cellular bioenergetics. ...Constitutive InsP(3)R Ca(2+) signaling is required for macroautophagy suppression in cells in nutrient-replete media. In its absence, cells become metabolically compromised due to diminished mitochondrial Ca(2+) uptake. ...
Here we identified an unexpected and essential role for constitutive InsP(3)R-mediated Ca(2+) release in maintaining cellular bioener …
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