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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.
Science. 2011.
PMID: 22053050
Free PMC article.
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.
Possemato R, et al.
Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.
Nature. 2011.
PMID: 21760589
Free PMC article.
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Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.
Sheen JH, Zoncu R, Kim D, Sabatini DM.
Sheen JH, et al.
Cancer Cell. 2011 May 17;19(5):613-28. doi: 10.1016/j.ccr.2011.03.012.
Cancer Cell. 2011.
PMID: 21575862
Free PMC article.
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