R01 CA129105-05/CA/NCI NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2011	7
2012	5
2022	0

1

mTOR signaling in growth control and disease.

Laplante M, Sabatini DM. Laplante M, et al. Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. Cell. 2012. PMID: 22500797 Free PMC article. Review.

2

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Possemato R, et al. Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350. Nature. 2011. PMID: 21760589 Free PMC article.

3

A unifying model for mTORC1-mediated regulation of mRNA translation.

Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM. Thoreen CC, et al. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. Nature. 2012. PMID: 22552098 Free PMC article.

4

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Lamming DW, et al. Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135. Science. 2012. PMID: 22461615 Free PMC article.

5

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. Hsu PP, et al. Science. 2011 Jun 10;332(6035):1317-22. doi: 10.1126/science.1199498. Science. 2011. PMID: 21659604 Free PMC article.

6

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. Peterson TR, et al. Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034. Cell. 2011. PMID: 21816276 Free PMC article.

7

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. Robida-Stubbs S, et al. Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007. Cell Metab. 2012. PMID: 22560223 Free PMC article.

8

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. Liu Q, et al. J Med Chem. 2011 Mar 10;54(5):1473-80. doi: 10.1021/jm101520v. Epub 2011 Feb 15. J Med Chem. 2011. PMID: 21322566 Free PMC article.

9

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

Sheen JH, Zoncu R, Kim D, Sabatini DM. Sheen JH, et al. Cancer Cell. 2011 May 17;19(5):613-28. doi: 10.1016/j.ccr.2011.03.012. Cancer Cell. 2011. PMID: 21575862 Free PMC article.

10

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.

Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS. Liu Q, et al. J Biol Chem. 2012 Mar 23;287(13):9742-9752. doi: 10.1074/jbc.M111.304485. Epub 2012 Jan 5. J Biol Chem. 2012. PMID: 22223645 Free PMC article.

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