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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 5
2013 1
2014 1
2015 4
2016 6
2017 5
2018 1
2019 1
2020 0
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22 results
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AMPK: guardian of metabolism and mitochondrial homeostasis.
Herzig S, Shaw RJ. Herzig S, et al. Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135. doi: 10.1038/nrm.2017.95. Epub 2017 Oct 4. Nat Rev Mol Cell Biol. 2018. PMID: 28974774 Free PMC article. Review.
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.
Garcia D, Shaw RJ. Garcia D, et al. Mol Cell. 2017 Jun 15;66(6):789-800. doi: 10.1016/j.molcel.2017.05.032. Mol Cell. 2017. PMID: 28622524 Free PMC article. Review.
Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
Toyama EQ, Herzig S, Courchet J, Lewis TL Jr, Losón OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ. Toyama EQ, et al. Science. 2016 Jan 15;351(6270):275-281. doi: 10.1126/science.aab4138. Science. 2016. PMID: 26816379 Free PMC article.
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.
Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. Egan DF, et al. Mol Cell. 2015 Jul 16;59(2):285-97. doi: 10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25. Mol Cell. 2015. PMID: 26118643 Free PMC article.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Bar-Peled L, et al. Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28. Cell. 2017. PMID: 28965760 Free PMC article.
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.
Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. Garcia D, et al. Cell Rep. 2019 Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036. Cell Rep. 2019. PMID: 30605676 Free PMC article.
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Howell JJ, et al. Cell Metab. 2017 Feb 7;25(2):463-471. doi: 10.1016/j.cmet.2016.12.009. Epub 2017 Jan 12. Cell Metab. 2017. PMID: 28089566 Free PMC article.
LKB1 promotes metabolic flexibility in response to energy stress.
Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. Parker SJ, et al. Metab Eng. 2017 Sep;43(Pt B):208-217. doi: 10.1016/j.ymben.2016.12.010. Epub 2016 Dec 26. Metab Eng. 2017. PMID: 28034771 Free PMC article.
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.
Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ Jr, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. Svensson RU, et al. Nat Med. 2016 Oct;22(10):1108-1119. doi: 10.1038/nm.4181. Epub 2016 Sep 19. Nat Med. 2016. PMID: 27643638 Free PMC article.
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.
Svensson RU, Shaw RJ. Svensson RU, et al. Cold Spring Harb Symp Quant Biol. 2016;81:93-103. doi: 10.1101/sqb.2016.81.030874. Epub 2017 Jan 6. Cold Spring Harb Symp Quant Biol. 2016. PMID: 28062532 Review.
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