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Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.

Boussiotis VA. Boussiotis VA. N Engl J Med. 2016 Nov 3;375(18):1767-1778. doi: 10.1056/NEJMra1514296. N Engl J Med. 2016. PMID: 27806234 Free PMC article. Review. No abstract available.

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Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.

Strauss L, Mahmoud MAA, Weaver JD, Tijaro-Ovalle NM, Christofides A, Wang Q, Pal R, Yuan M, Asara J, Patsoukis N, Boussiotis VA. Strauss L, et al. Sci Immunol. 2020 Jan 3;5(43):eaay1863. doi: 10.1126/sciimmunol.aay1863. Sci Immunol. 2020. PMID: 31901074 Free PMC article.

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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA. Patsoukis N, et al. Nat Commun. 2015 Mar 26;6:6692. doi: 10.1038/ncomms7692. Nat Commun. 2015. PMID: 25809635 Free PMC article.

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Immunotherapies for malignant glioma.

Boussiotis VA, Charest A. Boussiotis VA, et al. Oncogene. 2018 Mar;37(9):1121-1141. doi: 10.1038/s41388-017-0024-z. Epub 2017 Dec 15. Oncogene. 2018. PMID: 29242608 Free PMC article. Review.

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The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.

Bardhan K, Anagnostou T, Boussiotis VA. Bardhan K, et al. Front Immunol. 2016 Dec 12;7:550. doi: 10.3389/fimmu.2016.00550. eCollection 2016. Front Immunol. 2016. PMID: 28018338 Free PMC article. Review.

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Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy.

Le Bourgeois T, Strauss L, Aksoylar HI, Daneshmandi S, Seth P, Patsoukis N, Boussiotis VA. Le Bourgeois T, et al. Front Oncol. 2018 Aug 3;8:237. doi: 10.3389/fonc.2018.00237. eCollection 2018. Front Oncol. 2018. PMID: 30123774 Free PMC article. Review.

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Clinical significance of T cell metabolic reprogramming in cancer.

Herbel C, Patsoukis N, Bardhan K, Seth P, Weaver JD, Boussiotis VA. Herbel C, et al. Clin Transl Med. 2016 Dec;5(1):29. doi: 10.1186/s40169-016-0110-9. Epub 2016 Aug 10. Clin Transl Med. 2016. PMID: 27510264 Free PMC article. Review.

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Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2.

Christofides A, Karantanos T, Bardhan K, Boussiotis VA. Christofides A, et al. Oncotarget. 2016 Dec 20;7(51):85624-85640. doi: 10.18632/oncotarget.12928. Oncotarget. 2016. PMID: 27793053 Free PMC article. Review.

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Biochemical signaling of PD-1 on T cells and its functional implications.

Boussiotis VA, Chatterjee P, Li L. Boussiotis VA, et al. Cancer J. 2014 Jul-Aug;20(4):265-71. doi: 10.1097/PPO.0000000000000059. Cancer J. 2014. PMID: 25098287 Free PMC article. Review.

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The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation.

Politikos I, Boussiotis VA. Politikos I, et al. Blood. 2014 Nov 20;124(22):3201-11. doi: 10.1182/blood-2014-07-589176. Epub 2014 Oct 6. Blood. 2014. PMID: 25287708 Free PMC article. Review.

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