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Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19+ malignancy.
J Immunother Cancer. 2022 Dec;10(12):e005934. doi: 10.1136/jitc-2022-005934.
J Immunother Cancer. 2022.
PMID: 36521930
Free PMC article.
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory.
Viaud S, Ma JSY, Hardy IR, Hampton EN, Benish B, Sherwood L, Nunez V, Ackerman CJ, Khialeeva E, Weglarz M, Lee SC, Woods AK, Young TS.
Viaud S, et al.
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10898-E10906. doi: 10.1073/pnas.1810060115. Epub 2018 Oct 29.
Proc Natl Acad Sci U S A. 2018.
PMID: 30373813
Free PMC article.
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