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The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α.
Ren X, Keeney JTR, Miriyala S, Noel T, Powell DK, Chaiswing L, Bondada S, St Clair DK, Butterfield DA. Ren X, et al. Free Radic Biol Med. 2019 Apr;134:1-8. doi: 10.1016/j.freeradbiomed.2018.12.029. Epub 2018 Dec 26. Free Radic Biol Med. 2019. PMID: 30593843 Free PMC article.
Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain").
Keeney JTR, Ren X, Warrier G, Noel T, Powell DK, Brelsfoard JM, Sultana R, Saatman KE, Clair DKS, Butterfield DA. Keeney JTR, et al. Oncotarget. 2018 Jul 13;9(54):30324-30339. doi: 10.18632/oncotarget.25718. eCollection 2018 Jul 13. Oncotarget. 2018. PMID: 30100992 Free PMC article.