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Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures.
Monastyrskyi A, Brockmeyer F, LaCrue AN, Zhao Y, Maher SP, Maignan JR, Padin-Irizarry V, Sakhno YI, Parvatkar PT, Asakawa AH, Huang L, Casandra D, Mashkouri S, Kyle DE, Manetsch R. Monastyrskyi A, et al. J Med Chem. 2021 May 27;64(10):6581-6595. doi: 10.1021/acs.jmedchem.0c01104. Epub 2021 May 12. J Med Chem. 2021. PMID: 33979164 Free PMC article.
Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.
Neelarapu R, Maignan JR, Lichorowic CL, Monastyrskyi A, Mutka TS, LaCrue AN, Blake LD, Casandra D, Mashkouri S, Burrows JN, Willis PA, Kyle DE, Manetsch R. Neelarapu R, et al. J Med Chem. 2018 Feb 22;61(4):1450-1473. doi: 10.1021/acs.jmedchem.7b00738. Epub 2018 Feb 9. J Med Chem. 2018. PMID: 29215279 Free PMC article.
18 results