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2018 2
2020 2
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Page 1
Necroptosis: MLKL Polymerization.
Johnston A, Wang Z. Johnston A, et al. J Nat Sci. 2018 Jul;4(7):e513. J Nat Sci. 2018. PMID: 30294675 Free PMC article.
CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis.
Hanna-Addams S, Liu S, Liu H, Chen S, Wang Z. Hanna-Addams S, et al. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):1962-1970. doi: 10.1073/pnas.1917112117. Epub 2020 Jan 13. Proc Natl Acad Sci U S A. 2020. PMID: 31932442 Free PMC article.
Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis.
Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z. Johnston AN, et al. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6521-6530. doi: 10.1073/pnas.1916503117. Epub 2020 Mar 10. Proc Natl Acad Sci U S A. 2020. PMID: 32156734 Free PMC article.