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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 3
2009 8
2010 6
2011 7
2012 4
2013 1
2014 3
2015 1
2019 1
2020 1
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2024 0

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32 results

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Page 1
The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA. Ranek MJ, et al. Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30. Nature. 2019. PMID: 30700906 Free PMC article.
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA. Lee DI, et al. Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18. Nature. 2015. PMID: 25799991 Free PMC article.
PDE5 inhibitor efficacy is estrogen dependent in female heart disease.
Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. Sasaki H, et al. J Clin Invest. 2014 Jun;124(6):2464-71. doi: 10.1172/JCI70731. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837433 Free PMC article.
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.
Seo K, Rainer PP, Shalkey Hahn V, Lee DI, Jo SH, Andersen A, Liu T, Xu X, Willette RN, Lepore JJ, Marino JP Jr, Birnbaumer L, Schnackenberg CG, Kass DA. Seo K, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. doi: 10.1073/pnas.1308963111. Epub 2014 Jan 22. Proc Natl Acad Sci U S A. 2014. PMID: 24453217 Free PMC article.
Nitroxyl (HNO): A novel approach for the acute treatment of heart failure.
Sabbah HN, Tocchetti CG, Wang M, Daya S, Gupta RC, Tunin RS, Mazhari R, Takimoto E, Paolocci N, Cowart D, Colucci WS, Kass DA. Sabbah HN, et al. Circ Heart Fail. 2013 Nov;6(6):1250-8. doi: 10.1161/CIRCHEARTFAILURE.113.000632. Epub 2013 Oct 9. Circ Heart Fail. 2013. PMID: 24107588 Free PMC article. Clinical Trial.
32 results