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Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome.

Jaffré F, Miller CL, Schänzer A, Evans T, Roberts AE, Hahn A, Kontaridis MI. Jaffré F, et al. Circulation. 2019 Jul 16;140(3):207-224. doi: 10.1161/CIRCULATIONAHA.118.037227. Epub 2019 Jun 5. Circulation. 2019. PMID: 31163979 Free PMC article.

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Metformin protects against infection-induced myocardial dysfunction.

Tzanavari T, Varela A, Theocharis S, Ninou E, Kapelouzou A, Cokkinos DV, Kontaridis MI, Karalis KP. Tzanavari T, et al. Metabolism. 2016 Oct;65(10):1447-58. doi: 10.1016/j.metabol.2016.06.012. Epub 2016 Jul 9. Metabolism. 2016. PMID: 27621180 Free PMC article.

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The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.

Lauriol J, Jaffré F, Kontaridis MI. Lauriol J, et al. Semin Cell Dev Biol. 2015 Jan;37:73-81. doi: 10.1016/j.semcdb.2014.09.013. Epub 2014 Sep 22. Semin Cell Dev Biol. 2015. PMID: 25256404 Free PMC article. Review.

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How to get a K award: it is not just about the science.

Kontaridis MI. Kontaridis MI. Circ Res. 2014 Mar 14;114(6):941-3. doi: 10.1161/CIRCRESAHA.113.302994. Circ Res. 2014. PMID: 24625724 Free PMC article. No abstract available.

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Physiology of Cardiac Development: From Genetics to Signaling to Therapeutic Strategies.

Sun C, Kontaridis MI. Sun C, et al. Curr Opin Physiol. 2018 Feb;1:123-139. doi: 10.1016/j.cophys.2017.09.002. Epub 2017 Dec 13. Curr Opin Physiol. 2018. PMID: 29532042 Free PMC article.

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Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.

Zheng H, Yu WM, Waclaw RR, Kontaridis MI, Neel BG, Qu CK. Zheng H, et al. Sci Signal. 2018 Mar 20;11(522):eaao1591. doi: 10.1126/scisignal.aao1591. Sci Signal. 2018. PMID: 29559584 Free PMC article.

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Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.

Wang J, Mizui M, Zeng LF, Bronson R, Finnell M, Terhorst C, Kyttaris VC, Tsokos GC, Zhang ZY, Kontaridis MI. Wang J, et al. J Clin Invest. 2016 Jun 1;126(6):2077-92. doi: 10.1172/JCI87037. Epub 2016 May 16. J Clin Invest. 2016. PMID: 27183387 Free PMC article.

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DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.

Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S. Simonson B, et al. Sci Signal. 2017 Feb 28;10(468):eaaf5967. doi: 10.1126/scisignal.aaf5967. Sci Signal. 2017. PMID: 28246202 Free PMC article.

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The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach.

Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, MacRae CA, Messiaen L, Mulero-Navarro S, Neel B, Plotkin S, Rauen KA, Roberts A, Silva AJ, Sittampalam SG, Zhang C, Schoyer L. Korf B, et al. Am J Med Genet A. 2015 Aug;167A(8):1741-6. doi: 10.1002/ajmg.a.37089. Epub 2015 Apr 21. Am J Med Genet A. 2015. PMID: 25900621 Free PMC article.

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In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy.

Wang J, Chandrasekhar V, Abbadessa G, Yu Y, Schwartz B, Kontaridis MI. Wang J, et al. PLoS One. 2017 Jun 5;12(6):e0178905. doi: 10.1371/journal.pone.0178905. eCollection 2017. PLoS One. 2017. PMID: 28582432 Free PMC article.

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