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Mitotic progression following DNA damage enables pattern recognition within micronuclei.

Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA. Harding SM, et al. Nature. 2017 Aug 24;548(7668):466-470. doi: 10.1038/nature23470. Epub 2017 Jul 31. Nature. 2017. PMID: 28759889 Free PMC article.

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Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics.

Smith LR, Cho S, Discher DE. Smith LR, et al. Physiology (Bethesda). 2018 Jan 1;33(1):16-25. doi: 10.1152/physiol.00026.2017. Physiology (Bethesda). 2018. PMID: 29212889 Free PMC article. Review.

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Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPα structure-function.

Jalil AR, Andrechak JC, Discher DE. Jalil AR, et al. Antib Ther. 2020 Apr;3(2):80-94. doi: 10.1093/abt/tbaa006. Epub 2020 Apr 18. Antib Ther. 2020. PMID: 32421049 Free PMC article. Review.

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Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE. Cho S, et al. Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16. Dev Cell. 2019. PMID: 31105008 Free PMC article.

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Nuclear mechanosensing.

Xia Y, Pfeifer CR, Cho S, Discher DE, Irianto J. Xia Y, et al. Emerg Top Life Sci. 2018 Dec;2(5):713-725. doi: 10.1042/ETLS20180051. Epub 2018 Dec 21. Emerg Top Life Sci. 2018. PMID: 31693005 Free PMC article.

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Forced Unfolding of Proteins Directs Biochemical Cascades.

Saini K, Discher DE. Saini K, et al. Biochemistry. 2019 Dec 10;58(49):4893-4902. doi: 10.1021/acs.biochem.9b00839. Epub 2019 Nov 25. Biochemistry. 2019. PMID: 31736312 Review.

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From DNA damage to epithelial integrity: new roles for cell forces.

Discher DE. Discher DE. Mol Biol Cell. 2019 Jul 22;30(16):1879-1881. doi: 10.1091/mbc.E19-06-0338. Mol Biol Cell. 2019. PMID: 31322996 Free PMC article. No abstract available.

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Constricted migration modulates stem cell differentiation.

Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE. Smith LR, et al. Mol Biol Cell. 2019 Jul 22;30(16):1985-1999. doi: 10.1091/mbc.E19-02-0090. Epub 2019 Jun 12. Mol Biol Cell. 2019. PMID: 31188712 Free PMC article.

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Mechanotransduction in cancer.

Chin L, Xia Y, Discher DE, Janmey PA. Chin L, et al. Curr Opin Chem Eng. 2016 Feb;11:77-84. doi: 10.1016/j.coche.2016.01.011. Epub 2016 Feb 16. Curr Opin Chem Eng. 2016. PMID: 28344926 Free PMC article.

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SnapShot: Mechanosensing Matrix.

Irianto J, Pfeifer CR, Xia Y, Discher DE. Irianto J, et al. Cell. 2016 Jun 16;165(7):1820-1820.e1. doi: 10.1016/j.cell.2016.06.002. Cell. 2016. PMID: 27315485 Free PMC article.

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