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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.
Mol Neurodegener. 2007 Sep 26;2:18. doi: 10.1186/1750-1326-2-18.
Mol Neurodegener. 2007.
PMID: 17897471
Free PMC article.
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG.
Mamikonyan G, et al.
J Biol Chem. 2007 Aug 3;282(31):22376-86. doi: 10.1074/jbc.M700088200. Epub 2007 Jun 1.
J Biol Chem. 2007.
PMID: 17545160
Free PMC article.
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