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Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition.
Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-DeMotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA. Jaeger LB, et al. J Alzheimers Dis. 2009;17(3):553-70. doi: 10.3233/JAD-2009-1074. J Alzheimers Dis. 2009. PMID: 19433890 Free PMC article.
Transport of prion protein across the blood-brain barrier.
Banks WA, Robinson SM, Diaz-Espinoza R, Urayama A, Soto C. Banks WA, et al. Exp Neurol. 2009 Jul;218(1):162-7. doi: 10.1016/j.expneurol.2009.04.025. Epub 2009 May 5. Exp Neurol. 2009. PMID: 19422824 Free PMC article.