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Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease.

Nissanka N, Moraes CT. Nissanka N, et al. FEBS Lett. 2018 Mar;592(5):728-742. doi: 10.1002/1873-3468.12956. Epub 2018 Jan 9. FEBS Lett. 2018. PMID: 29281123 Free PMC article. Review.

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Cybrid technology.

Bacman SR, Nissanka N, Moraes CT. Bacman SR, et al. Methods Cell Biol. 2020;155:415-439. doi: 10.1016/bs.mcb.2019.11.025. Epub 2019 Dec 30. Methods Cell Biol. 2020. PMID: 32183971

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Nuclear-Mitochondrial Interactions.

Walker BR, Moraes CT. Walker BR, et al. Biomolecules. 2022 Mar 10;12(3):427. doi: 10.3390/biom12030427. Biomolecules. 2022. PMID: 35327619 Free PMC article. Review.

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Mechanisms of Mitochondrial DNA Deletion Formation.

Nissanka N, Minczuk M, Moraes CT. Nissanka N, et al. Trends Genet. 2019 Mar;35(3):235-244. doi: 10.1016/j.tig.2019.01.001. Epub 2019 Jan 25. Trends Genet. 2019. PMID: 30691869 Review.

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Mechanisms linking mtDNA damage and aging.

Pinto M, Moraes CT. Pinto M, et al. Free Radic Biol Med. 2015 Aug;85:250-8. doi: 10.1016/j.freeradbiomed.2015.05.005. Epub 2015 May 13. Free Radic Biol Med. 2015. PMID: 25979659 Free PMC article. Review.

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NO control of mitochondrial function in normal and transformed cells.

Tengan CH, Moraes CT. Tengan CH, et al. Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):573-581. doi: 10.1016/j.bbabio.2017.02.009. Epub 2017 Feb 16. Biochim Biophys Acta Bioenerg. 2017. PMID: 28216426 Free PMC article. Review.

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Mitochondrial genome changes and neurodegenerative diseases.

Pinto M, Moraes CT. Pinto M, et al. Biochim Biophys Acta. 2014 Aug;1842(8):1198-207. doi: 10.1016/j.bbadis.2013.11.012. Epub 2013 Nov 16. Biochim Biophys Acta. 2014. PMID: 24252612 Free PMC article. Review.

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DNA-editing enzymes as potential treatments for heteroplasmic mtDNA diseases.

Zekonyte U, Bacman SR, Moraes CT. Zekonyte U, et al. J Intern Med. 2020 Jun;287(6):685-697. doi: 10.1111/joim.13055. Epub 2020 Apr 27. J Intern Med. 2020. PMID: 32176378 Free PMC article. Review.

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Current strategies towards therapeutic manipulation of mtDNA heteroplasmy.

Pereira CV, Moraes CT. Pereira CV, et al. Front Biosci (Landmark Ed). 2017 Jan 1;22(6):991-1010. doi: 10.2741/4529. Front Biosci (Landmark Ed). 2017. PMID: 27814659 Free PMC article. Review.

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Mouse models of Parkinson's disease associated with mitochondrial dysfunction.

Pickrell AM, Pinto M, Moraes CT. Pickrell AM, et al. Mol Cell Neurosci. 2013 Jul;55:87-94. doi: 10.1016/j.mcn.2012.08.002. Epub 2012 Aug 11. Mol Cell Neurosci. 2013. PMID: 22954895 Free PMC article. Review.

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