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A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.
Curr Biol. 1998 Nov 5;8(22):1235-8. doi: 10.1016/s0960-9822(07)00517-9.
Curr Biol. 1998.
PMID: 9811606
Free article.
Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4.
Bresnahan PA, Yonemoto W, Greene WC.
Bresnahan PA, et al.
J Immunol. 1999 Sep 15;163(6):2977-81.
J Immunol. 1999.
PMID: 10477559
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