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Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and STAT3.
Guha P, Bandyopadhyaya G, Polumuri SK, Chumsri S, Gade P, Kalvakolanu DV, Ahmed H. Guha P, et al. Breast Cancer Res Treat. 2014 May;145(1):5-22. doi: 10.1007/s10549-014-2912-z. Epub 2014 Mar 26. Breast Cancer Res Treat. 2014. PMID: 24668500 Free PMC article.