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Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease.
Zhang C, Kuo CC, Moghadam SH, Monte L, Campbell SN, Rice KC, Sawchenko PE, Masliah E, Rissman RA. Zhang C, et al. Alzheimers Dement. 2016 May;12(5):527-37. doi: 10.1016/j.jalz.2015.09.007. Epub 2015 Nov 7. Alzheimers Dement. 2016. PMID: 26555315 Free PMC article.
INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer's disease (AD), but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long-term safety in ani …
INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer's
Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer’s Disease Transgenic Mouse Model.
Zhang C, Kuo CC, Moghadam SH, Monte L, Rice KC, Rissman RA. Zhang C, et al. J Alzheimers Dis. 2015;45(2):639-50. doi: 10.3233/JAD-141722. J Alzheimers Dis. 2015. PMID: 25649650 Free PMC article.
Reports from Alzheimer's disease (AD) biomarker work have shown a strong link between oxidative stress and AD neuropathology. ...Our results indicate that R121919 treatment can significantly reduce Pr-SSG levels and increase glutathione peroxide activi …
Reports from Alzheimer's disease (AD) biomarker work have shown a strong link between oxidative stress and AD neuropath …
Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice.
Zhang C, Rissman RA. Zhang C, et al. PLoS One. 2017 Jul 27;12(7):e0181367. doi: 10.1371/journal.pone.0181367. eCollection 2017. PLoS One. 2017. PMID: 28750017 Free PMC article.
Increased production of hydroxyl radical is the main source of oxidative damage in mammalian DNA that accumulates in Alzheimer's disease (AD). Reactive oxygen species (ROS) react with both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) to generate 8-hydroxy …
Increased production of hydroxyl radical is the main source of oxidative damage in mammalian DNA that accumulates in Alzheimer's
Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor.
Campbell SN, Zhang C, Monte L, Roe AD, Rice KC, Taché Y, Masliah E, Rissman RA. Campbell SN, et al. J Alzheimers Dis. 2015;43(3):967-76. doi: 10.3233/JAD-141281. J Alzheimers Dis. 2015. PMID: 25125464 Free PMC article.
Clinical and basic science research suggests that stress and/or changes in central stress signaling intermediates may be involved in Alzheimer's disease (AD) pathogenesis. Although the links between stress and AD remain unsettled, data from our group and othe …
Clinical and basic science research suggests that stress and/or changes in central stress signaling intermediates may be involved in Alzh
Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats.
Dong H, Keegan JM, Hong E, Gallardo C, Montalvo-Ortiz J, Wang B, Rice KC, Csernansky J. Dong H, et al. Psychoneuroendocrinology. 2018 Apr;90:92-101. doi: 10.1016/j.psyneuen.2018.02.013. Epub 2018 Feb 19. Psychoneuroendocrinology. 2018. PMID: 29477954 Free PMC article.
Mounting evidence suggests that chronic stress can alter brain structure and function and promote the development of neuropsychiatric disorders, such as depression and Alzheimer's disease. Although the results of several studies have indicated that aged brain …
Mounting evidence suggests that chronic stress can alter brain structure and function and promote the development of neuropsychiatric disord …
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.
Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG. Dong H, et al. Psychopharmacology (Berl). 2014 Dec;231(24):4711-22. doi: 10.1007/s00213-014-3629-8. Epub 2014 May 27. Psychopharmacology (Berl). 2014. PMID: 24862368 Free PMC article.
RATIONALE: Previous studies indicate that psychosocial stressors could accelerate amyloid-beta (Abeta) levels and accelerate plaque deposition in mouse models of Alzheimer disease (AD). Stressors enhanced the release of corticotrophin-releasing factor (CRF), and exo …
RATIONALE: Previous studies indicate that psychosocial stressors could accelerate amyloid-beta (Abeta) levels and accelerate plaque depositi …
Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation.
Rissman RA, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. Rissman RA, et al. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6277-82. doi: 10.1073/pnas.1203140109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451915 Free PMC article.
Exposure and/or sensitivity to stress have been implicated as conferring risk for development of Alzheimer's disease (AD). Although the basis for such a link remains unclear, we previously reported differential involvement of corticotropin-releasing factor re …
Exposure and/or sensitivity to stress have been implicated as conferring risk for development of Alzheimer's disease (A …