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Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure.
Lara A, Damasceno DD, Pires R, Gros R, Gomes ER, Gavioli M, Lima RF, Guimarães D, Lima P, Bueno CR Jr, Vasconcelos A, Roman-Campos D, Menezes CA, Sirvente RA, Salemi VM, Mady C, Caron MG, Ferreira AJ, Brum PC, Resende RR, Cruz JS, Gomez MV, Prado VF, de Almeida AP, Prado MA, Guatimosim S. Lara A, et al. Mol Cell Biol. 2010 Apr;30(7):1746-56. doi: 10.1128/MCB.00996-09. Epub 2010 Feb 1. Mol Cell Biol. 2010. PMID: 20123977 Free PMC article.
The vesicular acetylcholine transporter is required for neuromuscular development and function.
de Castro BM, De Jaeger X, Martins-Silva C, Lima RD, Amaral E, Menezes C, Lima P, Neves CM, Pires RG, Gould TW, Welch I, Kushmerick C, Guatimosim C, Izquierdo I, Cammarota M, Rylett RJ, Gomez MV, Caron MG, Oppenheim RW, Prado MA, Prado VF. de Castro BM, et al. Mol Cell Biol. 2009 Oct;29(19):5238-50. doi: 10.1128/MCB.00245-09. Epub 2009 Jul 27. Mol Cell Biol. 2009. PMID: 19635813 Free PMC article.