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HSP90 is a chaperone for DLK and is required for axon injury signaling.
Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9899-E9908. doi: 10.1073/pnas.1805351115. Epub 2018 Oct 1.
Proc Natl Acad Sci U S A. 2018.
PMID: 30275300
Free PMC article.
TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.
Frey E, Karney-Grobe S, Krolak T, Milbrandt J, DiAntonio A.
Frey E, et al.
eNeuro. 2018 May 30;5(3):ENEURO.0095-18.2018. doi: 10.1523/ENEURO.0095-18.2018. eCollection 2018 May-Jun.
eNeuro. 2018.
PMID: 29854941
Free PMC article.
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An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.
Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman LB, Giger RJ, DiAntonio A, Collins C.
Hao Y, et al.
Elife. 2016 Jun 7;5:e14048. doi: 10.7554/eLife.14048.
Elife. 2016.
PMID: 27268300
Free PMC article.
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Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.
Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A.
Valakh V, et al.
Neurobiol Dis. 2015 May;77:13-25. doi: 10.1016/j.nbd.2015.02.014. Epub 2015 Feb 26.
Neurobiol Dis. 2015.
PMID: 25726747
Free PMC article.
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An in vitro assay to study induction of the regenerative state in sensory neurons.
Frey E, Valakh V, Karney-Grobe S, Shi Y, Milbrandt J, DiAntonio A.
Frey E, et al.
Exp Neurol. 2015 Jan;263:350-63. doi: 10.1016/j.expneurol.2014.10.012. Epub 2014 Nov 4.
Exp Neurol. 2015.
PMID: 25447942
Free PMC article.
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