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Year Number of Results
2017 3
2018 12
2019 15
2020 3
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Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S. Pahuja KB, et al. Cancer Cell. 2018 Nov 12;34(5):792-806.e5. doi: 10.1016/j.ccell.2018.09.010. Epub 2018 Oct 25. Cancer Cell. 2018. PMID: 30449325 Free PMC article.
SNAC-tag for sequence-specific chemical protein cleavage.
Dang B, Mravic M, Hu H, Schmidt N, Mensa B, DeGrado WF. Dang B, et al. Nat Methods. 2019 Apr;16(4):319-322. doi: 10.1038/s41592-019-0357-3. Epub 2019 Mar 25. Nat Methods. 2019. PMID: 30923372 Free PMC article.
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. Aoyagi A, et al. Sci Transl Med. 2019 May 1;11(490):eaat8462. doi: 10.1126/scitranslmed.aat8462. Sci Transl Med. 2019. PMID: 31043574 Free PMC article.
In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.
Dregni AJ, Mandala VS, Wu H, Elkins MR, Wang HK, Hung I, DeGrado WF, Hong M. Dregni AJ, et al. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16357-16366. doi: 10.1073/pnas.1906839116. Epub 2019 Jul 29. Proc Natl Acad Sci U S A. 2019. PMID: 31358628 Free PMC article.
Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function.
Litvinov RI, Mravic M, Zhu H, Weisel JW, DeGrado WF, Bennett JS. Litvinov RI, et al. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12295-12300. doi: 10.1073/pnas.1904867116. Epub 2019 Jun 3. Proc Natl Acad Sci U S A. 2019. PMID: 31160446 Free PMC article.
Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals.
Zhang Q, Schepis A, Huang H, Yang J, Ma W, Torra J, Zhang SQ, Yang L, Wu H, Nonell S, Dong Z, Kornberg TB, Coughlin SR, Shu X. Zhang Q, et al. J Am Chem Soc. 2019 Mar 20;141(11):4526-4530. doi: 10.1021/jacs.8b13042. Epub 2019 Mar 6. J Am Chem Soc. 2019. PMID: 30821975 Free PMC article.
Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity.
Kang ES, Kim YT, Ko YS, Kim NH, Cho G, Huh YH, Kim JH, Nam J, Thach TT, Youn D, Kim YD, Yun WS, DeGrado WF, Kim SY, Hammond PT, Lee J, Kwon YU, Ha DH, Kim YH. Kang ES, et al. ACS Nano. 2018 Jul 24;12(7):6554-6562. doi: 10.1021/acsnano.8b01146. Epub 2018 Jun 4. ACS Nano. 2018. PMID: 29842775 Free PMC article.
Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. Zhang SQ, et al. Nat Chem Biol. 2018 Sep;14(9):870-875. doi: 10.1038/s41589-018-0105-5. Epub 2018 Jul 30. Nat Chem Biol. 2018. PMID: 30061717 Free PMC article.
De novo designed transmembrane peptides activating the α5β1 integrin.
Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF. Mravic M, et al. Protein Eng Des Sel. 2018 May 1;31(5):181-190. doi: 10.1093/protein/gzy014. Protein Eng Des Sel. 2018. PMID: 29992271 Free PMC article.
De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles.
Zhang SQ, Chino M, Liu L, Tang Y, Hu X, DeGrado WF, Lombardi A. Zhang SQ, et al. J Am Chem Soc. 2018 Jan 31;140(4):1294-1304. doi: 10.1021/jacs.7b08261. Epub 2018 Jan 22. J Am Chem Soc. 2018. PMID: 29249157 Free PMC article.
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