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Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.
Bioorg Med Chem Lett. 2008 Jun 15;18(12):3536-40. doi: 10.1016/j.bmcl.2008.05.020. Epub 2008 May 7.
Bioorg Med Chem Lett. 2008.
PMID: 18499455
Free PMC article.
QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
Kostakioti M, Hadjifrangiskou M, Pinkner JS, Hultgren SJ.
Kostakioti M, et al.
Mol Microbiol. 2009 Sep;73(6):1020-31. doi: 10.1111/j.1365-2958.2009.06826.x. Epub 2009 Aug 23.
Mol Microbiol. 2009.
PMID: 19703104
Free PMC article.
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