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Insulin receptor signaling in normal and insulin-resistant states.

Boucher J, Kleinridders A, Kahn CR. Boucher J, et al. Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1):a009191. doi: 10.1101/cshperspect.a009191. Cold Spring Harb Perspect Biol. 2014. PMID: 24384568 Free PMC article. Review.

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Insulin action in brain regulates systemic metabolism and brain function.

Kleinridders A, Ferris HA, Cai W, Kahn CR. Kleinridders A, et al. Diabetes. 2014 Jul;63(7):2232-43. doi: 10.2337/db14-0568. Epub 2014 Jun 15. Diabetes. 2014. PMID: 24931034 Free PMC article. Review.

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Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Softic S, et al. J Clin Invest. 2017 Nov 1;127(11):4059-4074. doi: 10.1172/JCI94585. Epub 2017 Oct 3. J Clin Invest. 2017. PMID: 28972537 Free PMC article.

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FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.

O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR. O'Neill BT, et al. Diabetes. 2019 Mar;68(3):556-570. doi: 10.2337/db18-0416. Epub 2018 Dec 6. Diabetes. 2019. PMID: 30523026 Free PMC article.

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Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.

Soto M, Herzog C, Pacheco JA, Fujisaka S, Bullock K, Clish CB, Kahn CR. Soto M, et al. Mol Psychiatry. 2018 Dec;23(12):2287-2301. doi: 10.1038/s41380-018-0086-5. Epub 2018 Jun 18. Mol Psychiatry. 2018. PMID: 29910467 Free PMC article.

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A guide to analysis of mouse energy metabolism.

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. Tschöp MH, et al. Nat Methods. 2011 Dec 28;9(1):57-63. doi: 10.1038/nmeth.1806. Nat Methods. 2011. PMID: 22205519 Free PMC article.

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Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.

Fujisaka S, Avila-Pacheco J, Soto M, Kostic A, Dreyfuss JM, Pan H, Ussar S, Altindis E, Li N, Bry L, Clish CB, Kahn CR. Fujisaka S, et al. Cell Rep. 2018 Mar 13;22(11):3072-3086. doi: 10.1016/j.celrep.2018.02.060. Cell Rep. 2018. PMID: 29539432 Free PMC article.

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FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.

Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, Kahn CR. Sakaguchi M, et al. Nat Commun. 2019 Apr 5;10(1):1582. doi: 10.1038/s41467-019-09418-0. Nat Commun. 2019. PMID: 30952843 Free PMC article.

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Insulin regulates astrocyte gliotransmission and modulates behavior.

Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR. Cai W, et al. J Clin Invest. 2018 Jul 2;128(7):2914-2926. doi: 10.1172/JCI99366. Epub 2018 Jun 4. J Clin Invest. 2018. PMID: 29664737 Free PMC article.

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Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. O'Neill BT, et al. J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15. J Clin Invest. 2016. PMID: 27525440 Free PMC article.

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