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Year Number of Results
2006 1
2007 3
2008 1
2009 2
2010 3
2011 7
2012 8
2013 6
2014 1
2016 1
2017 1
2019 1
2021 0
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34 results
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Page 1
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. Rasmussen SG, et al. Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361. Nature. 2011. PMID: 21772288 Free PMC article.
Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Liu X, et al. Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27. Science. 2019. PMID: 31249059 Free PMC article.
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK. Rasmussen SG, et al. Nature. 2011 Jan 13;469(7329):175-80. doi: 10.1038/nature09648. Nature. 2011. PMID: 21228869 Free PMC article.
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. Cherezov V, et al. Science. 2007 Nov 23;318(5854):1258-65. doi: 10.1126/science.1150577. Epub 2007 Oct 25. Science. 2007. PMID: 17962520 Free PMC article.
Visualization of arrestin recruitment by a G-protein-coupled receptor.
Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ. Shukla AK, et al. Nature. 2014 Aug 14;512(7513):218-222. doi: 10.1038/nature13430. Epub 2014 Jun 22. Nature. 2014. PMID: 25043026 Free PMC article.
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.
Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Ring AM, et al. Nature. 2013 Oct 24;502(7472):575-579. doi: 10.1038/nature12572. Epub 2013 Sep 22. Nature. 2013. PMID: 24056936 Free PMC article.
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Manglik A, et al. Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954. Nature. 2012. PMID: 22437502 Free PMC article.
Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Kruse AC, et al. Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867. Nature. 2012. PMID: 22358844 Free PMC article.
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Staus DP, et al. Nature. 2016 Jul 21;535(7612):448-52. doi: 10.1038/nature18636. Epub 2016 Jul 13. Nature. 2016. PMID: 27409812 Free PMC article.
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.
Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK. Liu X, et al. Nature. 2017 Aug 24;548(7668):480-484. doi: 10.1038/nature23652. Epub 2017 Aug 16. Nature. 2017. PMID: 28813418 Free PMC article.
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